Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus

The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gav...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-12, Vol.162 (2), p.269-272
Main Authors: Michurina, S. V., Ishchenko, I. Yu, Arkhipov, S. A., Klimontov, V. V., Rachkovskaya, L. N., Konenkov, V. I., Zavyalov, E. L.
Format: Article
Language:English
Subjects:
Aluminum
Aluminum oxide
Aluminum Oxide - chemistry
Analysis
Animals
Antioxidants - pharmacology
Arteries
Biomedical and Life Sciences
Biomedicine
Blood Glucose - metabolism
Cell Biology
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Disease Models, Animal
Endothelial cells
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Endothelial Cells - pathology
Endothelium
Female
Gene Expression - drug effects
Glycoproteins - agonists
Glycoproteins - genetics
Glycoproteins - metabolism
Hepatic Artery - drug effects
Hepatic Artery - metabolism
Hepatic Artery - pathology
Homozygote
Hyaluronic acid
Hyperglycemia - drug therapy
Hyperglycemia - genetics
Hyperglycemia - metabolism
Hyperglycemia - pathology
Internal Medicine
Laboratory Medicine
Liver
Liver - drug effects
Liver - metabolism
Liver - pathology
Lymphatic system
Lymphatic Vessels - drug effects
Lymphatic Vessels - metabolism
Lymphatic Vessels - pathology
Melatonin
Melatonin - pharmacology
Mice
Mice, Transgenic
Obesity
Obesity - drug therapy
Obesity - genetics
Obesity - metabolism
Obesity - pathology
Pathology
Receptors, Leptin - deficiency
Receptors, Leptin - genetics
Rodents
Silicones - chemistry
Type 2 diabetes
Veins
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Summary:The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to week 16 of life. The animals receiving the complex exhibited enhanced, in comparison with the placebo group, immunohistochemical LYVE-1+ staining of endothelial cells in sinusoids. Enhanced expression of LYVE-1 was associated with less pronounced dilatation of interlobular arteries, veins, and lymphatic vessels. Thee findings suggest a protective effect of the complex towards structural changes in the liver of mice with obesity and type 2 diabetes.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3592-y