A novel nano-silver coated and hydrogel-impregnated polyurethane nanofibrous mesh for ventral hernia repair

Clinically, patches for hernia repair have two existing concerns: antibacterial and tissue adhesion. The modification of medical device surfaces with antibacterial properties has recently shown to be an effective means to control bacterial-caused infection. On the other hand, hydrogel of gelatin and...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (93), p.90571-90578
Main Authors: Zhang, Shibin, Xu, Kaige, Ge, Liangpeng, Darabi, Mohammad Ali, Xie, Fei, Derakhshanfar, Soroosh, Liu, Yu, Xing, Malcolm M. Q., Wei, Hong
Format: Article
Language:English
Subjects:
Adhesion
Bacteria
Coating
Gelatins
Nanostructure
Polyethylene glycol
Polyurethane resins
Repair
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Clinically, patches for hernia repair have two existing concerns: antibacterial and tissue adhesion. The modification of medical device surfaces with antibacterial properties has recently shown to be an effective means to control bacterial-caused infection. On the other hand, hydrogel of gelatin and polyethylene glycol (PEG) has been verified for reducing tissue adhesion. Herein, we report a novel muscle-inspired and nano-silver coated, polyethyleneglycol (PEG)/gelatin hydrogel-impregnated polyurethane (NSPU) mesh. We hypothesize that an outside coated nano-silver is antiseptic to inflammations and infection. The PEG and gelatin hydrogel can remarkably reduce the postoperative adhesion in the abdomen; moreover, the flexible nanofibrous PU provides the necessary mechanical support as well. The composite mesh exhibited good antibacterial property in vitro . In vivo , after the implantation, it significantly reduced the postoperative adhesion in the abdomen compared to commercial polypropylene (PP) meshes. The composite also shows the graft accommodation in the abdominal wall tissue from hematoxylin–eosin (H&E) staining and immunohistochemistry analysis of CD3 (lymphocyte), CCR7 (M1 phenotype macrophage) and CD163 (M2 phenotype macrophage). Therefore, our NSPU mesh is promising for ventral hernia repair.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA10014G