Comparative study of singlet oxygen production by photosensitiser dyes encapsulated in silicone: towards rational design of anti-microbial surfaces

Surfaces with built-in antimicrobial activity have the potential to reduce hospital-acquired infections. One promising strategy is to create functionalised surfaces which, following illumination with visible light, are able to generate singlet oxygen under aerobic conditions. In contrast to antibiot...

Full description

Saved in:
Bibliographic Details
Published in:Physical chemistry chemical physics : PCCP 2016, Vol.18 (40), p.28101-28109
Main Authors: Noimark, Sacha, Salvadori, Enrico, Gómez-Bombarelli, Rafael, MacRobert, Alexander J, Parkin, Ivan P, Kay, Christopher W M
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemistry
Antiinfectives and antibacterials
Bacteria
Coloring Agents
Dyes
Electron Spin Resonance Spectroscopy
Encapsulation
Photosensitizing Agents - chemistry
Silicones
Silicones - chemistry
Singlet oxygen
Singlet Oxygen - chemistry
Spectroscopic analysis
Surface chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Surfaces with built-in antimicrobial activity have the potential to reduce hospital-acquired infections. One promising strategy is to create functionalised surfaces which, following illumination with visible light, are able to generate singlet oxygen under aerobic conditions. In contrast to antibiotics, the mechanism of bacterial kill by species derived from reactions with singlet oxygen is completely unselective, therefore offering little room for evolutionary adaptation. Here we consider five commercially available organic photosensitiser dyes encapsulated in silicone polymer that show varied antimicrobial activity. We correlate density functional theory calculations with UV-Vis spectroscopy, electron paramagnetic resonance spectroscopy and singlet oxygen production measurements in order to define and test the elements required for efficacious antimicrobial activity. Our approach forms the basis for the rational in silico design and spectroscopic screening of simple and efficient self-sterilising surfaces made from cheap, low toxicity photosensitiser dyes encapsulated in silicone.
ISSN:1463-9076
1463-9084
DOI:10.1039/c6cp02529c