On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity

In our continued search for novel trypanocidal compounds, arylamine, chalcone, triazolic, triazole-carbohydrate and chalcogenium derivatives containing a naphthoquinone scaffold were prepared; in addition to electrochemical studies, these compounds were evaluated against the infective bloodstream fo...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2015-09, Vol.5 (95), p.78047-78060
Main Authors: Jardim, Guilherme AM, Reis, Wallace J, Ribeiro, Matheus F, Ottoni, Flaviano M, Alves, Ricardo J, Silva, Thaissa L, Goulart, Marilia OF, Braga, Antonio L, Menna-Barreto, Rubem FS, Salomao, Kelly, de Castro, Solange L, da Silva Junior, Eufranio N
Format: Article
Language:English
Subjects:
Amines
Derivatives
Organic compounds
Quinones
Reagents
Searching
Synthesis
Trypanosoma cruzi
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In our continued search for novel trypanocidal compounds, arylamine, chalcone, triazolic, triazole-carbohydrate and chalcogenium derivatives containing a naphthoquinone scaffold were prepared; in addition to electrochemical studies, these compounds were evaluated against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. Among the thirty-eight compounds herein evaluated, six were found to be more potent against trypomastigotes than the standard drug benznidazole, with IC sub(50)/24 h values between 52.9 and 89.5 mu M.
ISSN:2046-2069
2046-2069
DOI:10.1039/c5ra16213k