Endometrial preparation with Dienogest before hysteroscopic surgery: a systematic review

Purpose Hysteroscopic surgery is considered the gold standard for the minimal invasive treatment of many endouterine diseases such as endometrial polyps or submucous myomas. Recently, many studies have evaluated the effect of preoperative administration of a number of drugs to reduce endometrial thi...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2017-03, Vol.295 (3), p.661-667
Main Authors: Laganà, Antonio Simone, Vitale, Salvatore Giovanni, Muscia, Vincenzo, Rossetti, Paola, Buscema, Massimo, Triolo, Onofrio, Rapisarda, Agnese Maria Chiara, Giunta, Loretta, Palmara, Vittorio, Granese, Roberta, Frangež, Helena Ban, Romano, Andrea
Format: Article
Language:English
Subjects:
Endocrinology
Endometrium - drug effects
Endometrium - pathology
Female
General Gynecology
Gynecology
Hormone replacement therapy
Human Genetics
Humans
Hysteroscopy - methods
Medicine
Medicine & Public Health
Nandrolone - analogs & derivatives
Nandrolone - therapeutic use
Obstetrics/Perinatology/Midwifery
Surgery
Systematic review
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Summary:Purpose Hysteroscopic surgery is considered the gold standard for the minimal invasive treatment of many endouterine diseases such as endometrial polyps or submucous myomas. Recently, many studies have evaluated the effect of preoperative administration of a number of drugs to reduce endometrial thickness and achieve important intraoperative advantages. The purpose of this systematic review is to summarize the available evidence about the use of Dienogest, an orally administrable progestin, for endometrial preparation before hysteroscopic surgery. Methods All studies published on this topic and indexed on PubMed/MEDLINE, Embase or Google scholar databases were retrieved and analysed. Results We retrieved five studies about this topic. Considered together, the published data analyses allow us to conclude that Dienogest is effective in reducing the thickness of the endometrium, the severity of bleeding and also of operative time, with a lower number of side effects compared with other pharmacological preparations or no treatment. Conclusion Administration of Dienogest may be an effective and safe treatment for endometrial thinning before operative hysteroscopy. However, this conclusion is based on few reports and further studies to prove or disprove it are warranted.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-016-4244-1