Cardiac extracellular matrix is associated with adverse outcome in patients with chronic heart failure

Aims Accumulation of extracellular matrix (ECM) is known to play a crucial role in the pathophysiology of heart failure (HF). However, its prognostic relevance is poorly investigated. Methods and results A total of 73 HF patients who underwent LV endomyocardial biopsy were enrolled in our study. ECM...

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Bibliographic Details
Published in:European journal of heart failure 2017-04, Vol.19 (4), p.502-511
Main Authors: Duca, Franz, Zotter‐Tufaro, Caroline, Kammerlander, Andreas A., Panzenböck, Adelheid, Aschauer, Stefan, Dalos, Daniel, Köll, Benedikt, Börries, Benedikt, Agis, Hermine, Kain, Renate, Aumayr, Klaus, Klinglmüller, Florian, Mascherbauer, Julia, Bonderman, Diana
Format: Article
Language:English
Subjects:
Aged
Atrial Pressure
Chronic Disease
Echocardiography, Doppler
Extracellular matrix
Extracellular Matrix - pathology
Female
Heart failure
Heart Failure - diagnostic imaging
Heart Failure - mortality
Heart Failure - pathology
Heart Failure - physiopathology
Heart Ventricles - pathology
Hospitalization
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Mortality
Myocardium - pathology
Outcome
Prognosis
Pulmonary Wedge Pressure
Stroke Volume
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Summary:Aims Accumulation of extracellular matrix (ECM) is known to play a crucial role in the pathophysiology of heart failure (HF). However, its prognostic relevance is poorly investigated. Methods and results A total of 73 HF patients who underwent LV endomyocardial biopsy were enrolled in our study. ECM area was quantified by TissueFAXS and ImageJ software. Patients were followed‐up at 6‐month intervals. The study endpoint was defined as hospitalization for a cardiac reason and/or cardiac death. Furthermore, the influence of the ECM on invasively measured haemodynamic parameters was tested. During a median follow‐up period of 9.0 months, 34 patients (46.6%) reached the combined endpoint. Median ECM area was 30.5%. Patients with ECM area ≥30.5% experienced significantly more events (67.6% vs. 25.0%, P < 0.001) in comparison with patients with an ECM area
ISSN:1388-9842
1879-0844
DOI:10.1002/ejhf.680