Reference Ranges of Fetal Cardiac Biometric Parameters Using Three-Dimensional Ultrasound with Spatiotemporal Image Correlation M Mode and Their Applicability in Congenital Heart Diseases

To determine reference values for fetal heart biometric parameters using the spatiotemporal image correlation (STIC) M mode and their applicability in congenital heart diseases (CHDs). A cross-sectional prospective study was conducted with 300 singleton pregnancies between 20 and 33 + 6 weeks of ges...

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Bibliographic Details
Published in:Pediatric cardiology 2017-02, Vol.38 (2), p.271-279
Main Authors: Tedesco, Giselle Darahem, de Souza Bezerra, Marilim, Barros, Fernanda Silveira Bello, Martins, Wellington P., Nardozza, Luciano Marcondes Machado, Carrilho, Milene Carvalho, Moron, Antonio Fernandes, Carvalho, Francisco Herlânio Costa, Rolo, Liliam Cristine, Araujo Júnior, Edward
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brazil
Cardiac Surgery
Cardiology
Congenital heart disease
Cross-Sectional Studies
Echocardiography, Three-Dimensional
Female
Fetal Heart - diagnostic imaging
Gestational Age
Heart Defects, Congenital - diagnostic imaging
Heart diseases
Heart Ventricles - diagnostic imaging
Humans
Medicine
Medicine & Public Health
Middle Aged
Original Article
Pregnancy
Prospective Studies
Reference Values
Regression Analysis
Reproducibility of Results
Ultrasonography, Prenatal
Vascular Surgery
Ventricular Septum - diagnostic imaging
Young Adult
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Summary:To determine reference values for fetal heart biometric parameters using the spatiotemporal image correlation (STIC) M mode and their applicability in congenital heart diseases (CHDs). A cross-sectional prospective study was conducted with 300 singleton pregnancies between 20 and 33 + 6 weeks of gestation. Right ventricular wall thickness (RVWT), interventricular septum thickness (IVST), and left ventricular wall thickness (LVWT) were measured off-line using the STIC-M mode with the cursor perpendicular to the interventricular septum. Polynomial regressions adjusted with the coefficient of determination ( R 2 ) were performed. The curves were applied to 14 fetuses with structural CHD. For the reproducibility calculations, the concordance correlation coefficient (CCC) was used. The mean RVWT, IVST, and LVWT were 0.34 ± 0.09 cm, 0.28 ± 0.09 cm, and 0.30 ± 0.07 cm, respectively. There was correlation between RVWT, IVST, and LVWT and gestational age (GA): RVWT = −0.002 + 0.013 × GA ( R 2  = 0.33), IVST = −0.011 + 0.011 × GA ( R 2  = 0.25), and LVWT = 0.056 + 0.009 × GA ( R 2  = 0.26). RVWT, IVST, and LVWT were altered (95th percentile) in 5/14, 5/14, and 7/14 of the fetuses with CHD, respectively. For RVWT, IVST, and LVWT, intra-observer (CCC = 0.86, 0.85, and 0.87, respectively) and inter-observer (CCC = 0.86, 0.86, and 0.86, respectively) reproducibility were good/moderate. The reference ranges determined for fetal heart biometric parameters using STIC-M had good intra- and inter-observer reproducibility and were applicable to fetuses with CHD.
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-016-1509-1