Effects of the ethanol extract of Cichorium intybus on the immunotoxicity by ethanol in mice

Effects of the ethanol extract of Cichorium intybus (CIEE) on the immunotoxicity of ethanol (EtOH) were investigated in ICR mice. Mice were divided into four groups, and CIEE at dose of 300 mg/kg was orally administered to mice daily for 28 consecutive days, and normal mice were given vehicle. Mice...

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Bibliographic Details
Published in:International immunopharmacology 2002-05, Vol.2 (6), p.733-744
Main Authors: Kim, Joung-Hoon, Mun, Yeun-Ja, Woo, Won-Hong, Jeon, Kyung-Soo, An, Nyeon-Hyoung, Park, Joung-Suk
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cichorium intybus
Cytokines - immunology
Cytokines - metabolism
Ethanol
Ethanol - toxicity
General pharmacology
Hypersensitivity, Delayed - chemically induced
Hypersensitivity, Delayed - drug therapy
Hypersensitivity, Delayed - immunology
Immunomodulators
Immunosuppressive Agents - toxicity
Immunotoxicity
Killer Cells, Natural - drug effects
Killer Cells, Natural - immunology
Liver - drug effects
Liver - immunology
Male
Medical sciences
Mice
Mice, Inbred ICR
Organ Size - drug effects
Organ Size - immunology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy - methods
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots
Sheep
Spleen - drug effects
Spleen - immunology
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Summary:Effects of the ethanol extract of Cichorium intybus (CIEE) on the immunotoxicity of ethanol (EtOH) were investigated in ICR mice. Mice were divided into four groups, and CIEE at dose of 300 mg/kg was orally administered to mice daily for 28 consecutive days, and normal mice were given vehicle. Mice treated with EtOH were given freely with 20% w/v EtOH solution. The results of this study are summarized as follows: The combination of CIEE and EtOH showed significant increases in the circulating leukocytes and the relative weights of liver, spleen and thymus, as compared with those in mice treated with EtOH alone. However, the body weight gain was not affected. Splenic plaque forming cells (PFC) and hemagglutination (HA) titers to sheep red blood cells (SRBC), and the secondary IgG antibody response to bovine serum albumin (BSA) were markedly enhanced by CIEE plus EtOH treatment as compared with the treatment of EtOH alone. In mice receiving the combination of CIEE and EtOH when compared with EtOH alone-treated mice, there were also significant increases in delayed-type hypersensitivity (DTH) reaction, phagocytic activity, natural killer (NK) cell activity and cell proliferation as well as interferon-γ (IFN-γ) secretion. In the case of interleukin-4 (IL-4) content, however, an insignificant induction observed by CIEE plus EtOH treatment. These findings indicate that the immunotoxicity induced by EtOH is significantly restored or prevented by CIEE treatment.
ISSN:1567-5769
1878-1705
DOI:10.1016/S1567-5769(02)00008-5