Airway reactivity response to aged carbon-graphite/epoxy composite material smoke

Exposure of na& uml;ve guinea pigs for a total of 30 min to aged smoke from pyrolysis of 5, 10 and 100 g of carbon–graphite/epoxy‐advanced composite material (cgeCM) elicited changes in the ventilation and breathing pattern reminiscent of an acute, asthmatic episode. The severity of these respon...

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Bibliographic Details
Published in:Journal of applied toxicology 2002-05, Vol.22 (3), p.193-206
Main Authors: Kimmel, Edgar C., Reboulet, James E., Courson, David L., Still, Kenneth R.
Format: Article
Language:English
Subjects:
airway reactivity
Animals
Biological and medical sciences
Bronchial Hyperreactivity - chemically induced
Bronchial Hyperreactivity - physiopathology
carbon-graphite/epoxy composite material
Chemical and industrial products toxicology. Toxic occupational diseases
Composite Resins - adverse effects
Dose-Response Relationship, Drug
Epoxy Compounds
Gas, fumes
Graphite
Guinea Pigs
Inhalation Exposure
Male
Medical sciences
Respiration - drug effects
Respiratory Physiological Phenomena - drug effects
smoke
Smoke - adverse effects
Smoke - analysis
Toxicology
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Summary:Exposure of na& uml;ve guinea pigs for a total of 30 min to aged smoke from pyrolysis of 5, 10 and 100 g of carbon–graphite/epoxy‐advanced composite material (cgeCM) elicited changes in the ventilation and breathing pattern reminiscent of an acute, asthmatic episode. The severity of these responses was dose related. Although breathing pattern changes were not definitive of stimulation by a single type of respiratory irritant, non‐dimensional indices derived from breath structure appeared to be characteristic of bronchoconstriction possibly complicated by CO2‐stimulated ventilation. The highest exposure concentration also elicited convulsions in the animals, which may or may not be related to the airway reactivity (AR) response. Upon treatment with fresh air, breathing returned to normal. However, this recovery was transient with some respiratory parameters returning to abnormal levels, possibly indicating a rebound or delayed component of the response. Filtration of particulate material from the smoke moderated but did not eliminate the AR response. Animals exposed to diluted smoke from the pyrolysis of 2 g of cgeCM showed no remarkable changes in breathing or ventilation, suggesting that there may be a threshold for aged cgeCM smoke‐elicited AR response. Published in 2002 by John Wiley & Sons, Ltd.
ISSN:0260-437X
1099-1263
DOI:10.1002/jat.849