Clinical Outcomes of Posterior Versus Anterior Circulation Infarction With Low National Institutes of Health Stroke Scale Scores

BACKGROUND AND PURPOSE—We compared baseline characteristics and outcomes at 3 months between patients with minor anterior circulation infarction (ACI) versus minor posterior circulation infarction (PCI), including the influence of large vessel disease on outcomes. METHODS—This study is an analysis o...

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Published in:Stroke (1970) 2017-01, Vol.48 (1), p.55-62
Main Authors: Kim, Joon-Tae, Park, Man-Seok, Choi, Kang-Ho, Kim, Beom Joon, Han, Moon-Ku, Park, Tai Hwan, Park, Sang-Soon, Lee, Kyung Bok, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Cha, Jae Kwan, Kim, Dae-Hyun, Nah, Hyun-Wook, Lee, Jun, Lee, Soo Joo, Ko, Youngchai, Kim, Jae Guk, Park, Jong-Moo, Kang, Kyusik, Cho, Yong-Jin, Hong, Keun-Sik, Choi, Jay Chol, Kim, Dong-Eog, Ryu, Wi-Sun, Shin, Dong-Ick, Yeo, Min-Ju, Kim, Wook-Joo, Lee, Juneyoung, Lee, Ji Sung, Bae, Hee-Joon, Saver, Jeffrey L, Cho, Ki-Hyun
Format: Article
Language:English
Subjects:
Aged
Cerebral Infarction - diagnosis
Cerebral Infarction - epidemiology
Female
Humans
Male
Middle Aged
National Institutes of Health (U.S.) - standards
Prospective Studies
Registries
Republic of Korea - epidemiology
Severity of Illness Index
Stroke - diagnosis
Stroke - epidemiology
Treatment Outcome
United States
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Summary:BACKGROUND AND PURPOSE—We compared baseline characteristics and outcomes at 3 months between patients with minor anterior circulation infarction (ACI) versus minor posterior circulation infarction (PCI), including the influence of large vessel disease on outcomes. METHODS—This study is an analysis of a prospective multicenter registry database in South Korea. Eligibility criteria were patients with ischemic stroke admitted within 7 days of stroke onset, lesions in either anterior or posterior circulation, and National Institutes of Health Stroke Scale score of ≤4 at baseline. Patients were divided into 4 groups for further analysisminor ACI with and without internal carotid artery/middle cerebral artery large vessel disease and minor PCI with and without vertebrobasilar large vessel disease. RESULTS—A total of 7178 patients (65.2±12.6 years) were analyzed in this study, and 2233 patients (31.1%) had disability (modified Rankin Scale score 2–6) at 3 months. Disability was 32.3% in minor PCI and 30.3% in minor ACI (P=0.07), and death was 1.3% and 1.5%, respectively (P=0.82). In a multivariable logistic regression analysis, minor PCI was significantly associated with disability at 3 months when compared with minor ACI (odds ratio, 1.23; 95% confidence interval, 1.09–1.37; P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.116.013432