Developmental toxicity: web resources for evaluating risk in humans

This review presents a brief overview of Internet resources that provides information on developmental toxicity. The advantages and limitations of these resources for evaluating human risk and where each one is useful for informing various stages of the risk assessment process (i.e. hazard character...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2002-04, Vol.173 (1-2), p.35-65
Main Authors: Polifka, Janine E., Faustman, Elaine M.
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced
Databases as Topic
Developmental and reproductive toxicity
Embryonic and Fetal Development - drug effects
Female
Humans
Information resources
Internet
Maternal Exposure - adverse effects
Pregnancy
Risk Assessment
Teratogens - toxicity
Teratology
Toluene
Toluene - toxicity
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Summary:This review presents a brief overview of Internet resources that provides information on developmental toxicity. The advantages and limitations of these resources for evaluating human risk and where each one is useful for informing various stages of the risk assessment process (i.e. hazard characterization, dose-response assessment, exposure assessment and risk characterization) are reviewed. How these Internet resources can be utilized to obtain information on and evaluate the developmental risk associated with exposures during pregnancy will be illustrated using toluene. Translating information derived from laboratory and human population studies into clinical management prescriptions for individual patients is difficult. With the increasing availability of Internet resources that provide information relevant for developmental risk assessments, health care professionals will be better equipped to make more accurate estimations of potential risk for their patients.
ISSN:0300-483X
1879-3185
DOI:10.1016/S0300-483X(02)00021-5