Prognostic Significance of Cereblon Expression in Patients With Multiple Myeloma

Micro-Abstract Within a personalized treatment approach in multiple myeloma (MM), the prognostic significance of cereblon ( CRBN ) expression was analyzed in 92 newly diagnosed patients. In patients treated with thalidomide-based combinations, CRBN expression significantly affected the treatment res...

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Bibliographic Details
Published in:Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2016-11, Vol.16 (11), p.610-615
Main Authors: Bila, Jelena, Sretenovic, Aleksandra, Jelicic, Jelena, Tosic, Natasa, Glumac, Irena, Fekete, Marija Dencic, Antic, Darko, Balint, Milena Todorovic, Markovic, Olivera, Milojevic, Zoran, Radojkovic, Milica, Trajkovic, Goran, Puric, Mila, Pavlovic, Sonja, Mihaljevic, Biljana
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
CRBN expression
Female
Gene Expression
Hematology, Oncology and Palliative Medicine
Humans
Immunomodulatory drugs
Kaplan-Meier Estimate
Male
Middle Aged
Multiple myeloma
Multiple Myeloma - diagnosis
Multiple Myeloma - genetics
Multiple Myeloma - mortality
Multiple Myeloma - therapy
Neoplasm Staging
Peptide Hydrolases - genetics
Prognosis
Treatment
Treatment Outcome
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Summary:Micro-Abstract Within a personalized treatment approach in multiple myeloma (MM), the prognostic significance of cereblon ( CRBN ) expression was analyzed in 92 newly diagnosed patients. In patients treated with thalidomide-based combinations, CRBN expression significantly affected the treatment response ( P  = .028) and progression-free survival ( P  = .017). With implications for the treatment outcome, measurement of CRBN expression might represent an additional prognostic tool in a personalized treatment approach.
ISSN:2152-2650
2152-2669
DOI:10.1016/j.clml.2016.08.007