Anhedonia and its correlation with clinical aspects in Parkinson's disease

Abstract Anhedonia is one of the non-motor symptoms observed in the Parkinson ' s disease (PD). However, there is no clear relationship between anhedonia and its correlation with other symptoms of PD. The aim of this study is to evaluate the characteristics of anhedonia and its correlation with...

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Published in:Journal of the neurological sciences 2017-01, Vol.372, p.403-407
Main Authors: Nagayama, Hiroshi, MD, PhD, Maeda, Tetsuya, MD, PhD, Uchiyama, Tsuyoshi, MD, PhD, Hashimoto, Masaya, MD, PhD, Nomoto, Nobuatsu, MD, PhD, Kano, Osamu, MD, PhD, Takahashi, Tatsuya, MD, PhD, Terashi, Hiroo, MD, PhD, Hamada, Shinsuke, MD, Hasegawa, Takafumi, MD, PhD, Hatano, Taku, MD, PhD, Takahashi, Tetsuya, MD, PhD, Baba, Yasuhiko, MD, PhD, Sengoku, Renpei, MD, PhD, Watanabe, Hirohisa, MD, PhD, Inoue, Manabu, MD, PhD, Kadowaki, Taro, MD, PhD, Kaneko, Satoshi, MD, PhD, Shimura, Hideki, MD, Kubo, Shin-ichiro, MD, PhD
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anhedonia
Anhedonia - physiology
Cohort Studies
Cross-Sectional Studies
Depression
Depression - epidemiology
Depression - etiology
Female
Humans
Japan
Male
Middle Aged
Neurology
Parkinson Disease - complications
Parkinson Disease - epidemiology
Parkinson Disease - psychology
Parkinson's disease
Psychiatric Status Rating Scales
Severity of Illness Index
Snaith–Hamilton Pleasure Scale
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Summary:Abstract Anhedonia is one of the non-motor symptoms observed in the Parkinson ' s disease (PD). However, there is no clear relationship between anhedonia and its correlation with other symptoms of PD. The aim of this study is to evaluate the characteristics of anhedonia and its correlation with clinical aspects of PD in a relatively large cohort. We enrolled 318 patients with PD and 62 control subjects for this study. Patients and subjects were tested using the Snaith–Hamilton Pleasure Scale Japanese version and the Beck Depression Inventory 2nd edition for the assessment of anhedonia and depression. We also investigated the correlation among clinical aspects of PD, anhedonia, and depression in patients with PD. The Snaith–Hamilton Pleasure Scale Japanese version and the Beck Depression Inventory 2nd edition scores were significantly higher in patients with PD than in control subjects (p = 0.03 and p = 0.0006, respectively). All PD patients with anhedonia had a significantly higher score on the unified Parkinson's disease rating scale (UPDRS) parts I and II compared to PD patients without anhedonia. Additionally, all PD patients with depression scored significantly higher on UPDRS part I –IV than PD patients without depression. The patients with anhedonia and without depression had mild motor severity and their treatment was relatively low dosage. These results suggest that anhedonia and depression are slightly linked, but not the same. PD patients with only anhedonia may be closely linked apathy found in untreated early stages of PD.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2016.10.051