Effect of T-2 toxin on in vivo lipid peroxidation and vitamin E status in mice

The effects of an acute administration of T-2 toxin on vitamin E status and the corresponding degree of lipid peroxidation, as determined by the plasma and organ content of malondialdehyde (MDA), was studied in mice. The effects of T-2 toxin administration on the body weight and weights of liver, sp...

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Bibliographic Details
Published in:Food and chemical toxicology 2002-04, Vol.40 (4), p.479-486
Main Authors: Vilà, B., Jaradat, Z.W., Marquardt, R.R., Frohlich, A.A.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Biological and medical sciences
Body Weight
Dose-Response Relationship, Drug
Female
Lipid peroxidation
Lipid Peroxidation - drug effects
Liver - pathology
MDA
Medical sciences
Mice
Plant poisons toxicology
Spleen - pathology
T-2 toxin
T-2 Toxin - adverse effects
Thymus Gland - pathology
Toxicology
Vitamin E
Vitamin E - blood
Vitamin E - metabolism
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Summary:The effects of an acute administration of T-2 toxin on vitamin E status and the corresponding degree of lipid peroxidation, as determined by the plasma and organ content of malondialdehyde (MDA), was studied in mice. The effects of T-2 toxin administration on the body weight and weights of liver, spleen and thymus were also assessed. T-2 toxin was administered in doses ranging from 1 to 6.25 mg/kg body weight, depending on the experiment, while the dietary content of vitamin E ranged from near 0 to 5000 IU/kg. There was a significant decrease in vitamin E content of plasma after the administration of the toxin with the concentrations remaining low for periods as long as 48–72 h. MDA content of liver increased significantly after 24–48 h of toxin administration in contrast to the controls. However, MDA levels returned to the control range after 72 h. The concentrations of MDA in liver were inversely related to the vitamin E content of the diet, and were always higher for the toxin-treated animals (significant linear regression between MDA content of liver and the log10 of vitamin E content of the diet). Weights of spleen and thymus decreased after T-2 toxin administration; however, the weight of liver either increased or did not change in the different experiments. In conclusion, T-2 toxin treatment of mice increased lipid peroxidation in the liver as measured by MDA production. This process was maximal after 48 h of T-2 challenge, and decreased thereafter. Plasma α-tocopherol levels decreased as soon as 6 h after the toxin challenge, while MDA did not increase until there was a severe depletion of vitamin E. These changes were accompanied by decrease in weight of spleen and thymus.
ISSN:0278-6915
1873-6351
DOI:10.1016/S0278-6915(01)00122-3