Short-term supplementation with a specific combination of dietary polyphenols increases energy expenditure and alters substrate metabolism in overweight subjects

Impaired regulation of lipid oxidation (metabolic inflexibility) is associated with obesity and type 2 diabetes mellitus. Recent evidence has indicated that dietary polyphenols may modulate mitochondrial function, substrate metabolism and energy expenditure in humans. The present study investigated...

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Bibliographic Details
Published in:International Journal of Obesity 2014-05, Vol.38 (5), p.698-706
Main Authors: MOST, J, GOOSSENS, G. H, JOCKEN, J. W. E, BLAAK, E. E
Format: Article
Language:English
Subjects:
Adult
Antioxidants - therapeutic use
Bioenergetics
Biological and medical sciences
Body fat
Body mass
Body Mass Index
Body size
Body weight
Calorimetry
Catechin - analogs & derivatives
Catechin - therapeutic use
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diet
Dietary Supplements
Double-Blind Method
Double-blind studies
Drug Therapy, Combination
Energy
Energy expenditure
Energy metabolism
Energy Metabolism - drug effects
Fasting
Fatty acids
Female
Flexibility
Glucose
Glycerol
Health aspects
Humans
Insulin resistance
Isoflavones
Lifestyles
Lipid Metabolism - drug effects
Lipid peroxidation
Lipids
Male
Medical sciences
Metabolic diseases
Metabolism
Metabolites
Middle Aged
Mitochondria
Musculoskeletal system
Obesity
Overweight
Overweight - diet therapy
Overweight - metabolism
Overweight persons
Oxidation
Oxidation-Reduction
Physiological aspects
Physiological research
Polyphenols
Polyphenols - therapeutic use
Postprandial Period
Quotients
Respiratory quotient
Resveratrol
Stilbenes - therapeutic use
Substrates
Toxicology
Treatment Outcome
Womens health
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Summary:Impaired regulation of lipid oxidation (metabolic inflexibility) is associated with obesity and type 2 diabetes mellitus. Recent evidence has indicated that dietary polyphenols may modulate mitochondrial function, substrate metabolism and energy expenditure in humans. The present study investigated the effects of short-term supplementation of two combinations of polyphenols on energy expenditure (EE) and substrate metabolism in overweight subjects. Eighteen healthy overweight volunteers (9 women, 9 men; age 35±2.5 years; body mass index 28.9±0.4 kg m(-2)) participated in a randomized, double-blind cross-over trial. Combinations of epigallocatechin-gallate (E, 282 mg day(-1))+resveratrol (R, 200 mg day(-1)) and E+R+80 mg day(-1) soy isoflavones (S) or placebo capsules (PLA) were supplemented twice daily for a period of 3 days. On day 3, circulating metabolite concentrations, EE and substrate oxidation (using indirect calorimetry) were measured during fasting and postprandial conditions for 6 h (high-fat-mixed meal (2.6 MJ, 61.2 E% fat)). Short-term supplementation of E+R increased resting EE (E+R vs PLA: 5.45±0.24 vs 5.23±0.25 kJ min(-1), P=0.039), whereas both E+R (699±18 kJ 120 min(-1) vs 676±20 kJ 120 min(-1), P=0.028) and E+R+S (704±18 kJ 120 min(-1) vs 676±20 kJ 120 min(-1), P=0.014) increased 2-4 h-postprandial EE compared with PLA. Metabolic flexibility, calculated as the postprandial increase to the highest respiratory quotient achieved, tended to be improved by E+R compared with PLA and E+R+S only in men (E+R vs PLA: 0.11±0.02 vs 0.06±0.02, P=0.059; E+R+S: 0.03±0.02, P=0.009). E+R+S significantly increased fasting plasma free fatty acid (P=0.064) and glycerol (P=0.021) concentrations compared with PLA. We demonstrated for the first time that combined E+R supplementation for 3 days significantly increased fasting and postprandial EE, which was accompanied by improved metabolic flexibility in men but not in women. Addition of soy isoflavones partially reversed these effects possibly due to their higher lipolytic potential. The present findings may imply that long-term supplementation of these dosages of epigallocatechin-gallate combined with resveratrol may improve metabolic health and body weight regulation.
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2013.231