Prevalence of depression in Type 1 diabetes and the problem of over-diagnosis

Aims To determine the prevalence of depression and diabetes distress in adults with Type 1 diabetes and the rate of false‐positives when compared with rates of major depressive disorder. Methods The sample consisted of 368 individuals with Type 1 diabetes, aged > 19 years. Individuals completed:...

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Bibliographic Details
Published in:Diabetic medicine 2016-11, Vol.33 (11), p.1590-1597
Main Authors: Fisher, L., Hessler, D. M., Polonsky, W. H., Masharani, U., Peters, A. L., Blumer, I., Strycker, L. A.
Format: Article
Language:English
Subjects:
Adult
Antidepressants
Chronic illnesses
Depression - diagnosis
Depression - epidemiology
Depression - etiology
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - epidemiology
Diabetes
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - psychology
False Positive Reactions
Female
Humans
Male
Medical Overuse - statistics & numerical data
Mental depression
Middle Aged
Prevalence
Psychometrics
Psychopathology
Questionnaires
Stress, Psychological - diagnosis
Stress, Psychological - epidemiology
Surveys and Questionnaires
Young Adult
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Summary:Aims To determine the prevalence of depression and diabetes distress in adults with Type 1 diabetes and the rate of false‐positives when compared with rates of major depressive disorder. Methods The sample consisted of 368 individuals with Type 1 diabetes, aged > 19 years. Individuals completed: the eight‐item Patient Health Questionnaire depression scale (PHQ8), which was coded using four scoring criteria (scores > 10, >12 and >15, and Diagnostic and Statistical Manual of Mental Disorders 5 (DSM) algorithm scores); the Type 1 Diabetes Distress Scale; and the Structured Clinical Interview for DSM Disorders (SCID) to assess major depressive disorder. Results The prevalence rates of depression according to the eight‐item Patient Health Questionnaire were: score >10, 11.4%; score >12, 7.1%; score >15, 3.8%; and positive algorithm result, 4.6%. The prevalence of major depressive disorder was 3.5%; and the prevalence of at least moderate diabetes distress was 42.1%. Depending on the criterion used, the false‐positive rate when using the Patient Health Questionnaire compared with the results when using the SCID varied from 52 to 71%. Of those classified as depressed on the PHQ‐8 or Structured Clinical Interview for DSM Disorders, between 92.3 and 96.2% also reported elevated diabetes distress. No significant association was found between any group classed as having depression according to the PHQ8 or the SCID and HbA1c concentration. Depression was significantly associated with more other life stress, more complications and a lower level of education. Conclusions We found an unexpectedly low rate of current depression and major depressive disorder in this diverse sample of adults with Type 1 diabetes, and a very high rate of false‐positive results using the Patient Health Questionnaire. Considering the high prevalence of diabetes distress, much of what has been considered depression in adults with Type 1 diabetes may be attributed to the emotional distress associated with managing a demanding chronic disease and other life stressors and not necessarily to underlying psychopathology. What's new? The prevalence of current depression in adults with Type 1 diabetes is far lower than commonly assumed, and is similar to rates reported in community populations. There are high rates of false‐positive results when comparing the eight‐iterm Patient Health Questionnaire and structured diagnostic interviews to identify major depressive disorder. The prevalence of significan
ISSN:0742-3071
1464-5491
DOI:10.1111/dme.12973