An Obesity Paradox: An Inverse Correlation between Body Mass Index and Atherosclerosis of the Aorta

Abstract Background and aims Morbid obesity generally has been associated with higher morbidity and mortality for a variety of diseases. However, a number of exceptions to this have been reported and referred to as the “obesity paradox.” The purpose of the present study was to obtain objective data...

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Bibliographic Details
Published in:Cardiovascular pathology 2016-11, Vol.25 (6), p.515-520
Main Authors: Brodsky, Sergey V, Barth, Rolf F, Mo, Xiaokui, Yildiz, Vedat, Allenby, Patricia, Ivanov, Iouri, Moore, Stephen, Hitchcock, Charles L, Smith, Stephen, Sachak, Taha, Yao, Keluo, Ball, Matthew, Rosborough, Kelly, Olson, Zachary, Kiehl, Micah, Muni, Navin, Virmani, Renu
Format: Article
Language:English
Subjects:
Adult
Aged
Aortic atherosclerosis
Aortic Diseases - epidemiology
Atherosclerosis - epidemiology
Autopsy
Body Mass Index
Body mass index (BMI)
Female
Humans
Hypertension - epidemiology
Male
Middle Aged
Obesity paradox
Obesity, Morbid - epidemiology
Pathology
Young Adult
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Summary:Abstract Background and aims Morbid obesity generally has been associated with higher morbidity and mortality for a variety of diseases. However, a number of exceptions to this have been reported and referred to as the “obesity paradox.” The purpose of the present study was to obtain objective data on aortic atherosclerosis and its relationship to body mass index (BMI, kg/m2 ), based on autopsy findings in a large cohort of overweight and obese decedents. Methods Decedents were≥19 years who had autopsies between 2003–2014, a subset of whomwere morbidly obese (BMI≥40). Autopsy findings were reviewed and compared to a control group (BMI
ISSN:1054-8807
1879-1336
DOI:10.1016/j.carpath.2016.09.002