New Priorities: Analysis of the New Kidney Allocation System on UCLA Patients Transplanted from the Deceased Donor Waitlist

Abstract UNOS implemented a new kidney allocation system (New KAS) on December 4, 2014 with a primary goal of increasing equity to organ transplant for patients that were immunologically or socially disadvantaged by the previous allocation system (Previous KAS) that prioritized long wait times. We e...

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Bibliographic Details
Published in:Human immunology 2017-01, Vol.78 (1), p.41-48
Main Authors: Hickey, Michelle J, Zheng, Ying, Valenzuela, Nicole, Zhang, Qiuheng, Krystal, Carolyn, Lum, Erik, Tsai, Eileen W, Lipshutz, Gerald S, Albin Gritsch, H, Danovitch, Gabriel, Veale, Jeffrey, Gjertson, David, Cecka, Michael, Reed, Elaine F
Format: Article
Language:English
Subjects:
Academic Medical Centers
Adolescent
Adult
Aged
Aged, 80 and over
Allergy and Immunology
Cadaver
Child
Child, Preschool
Clinical Protocols
Donor specific antibody
Female
Government Regulation
Histocompatibility Testing
HLA Antigens - immunology
Humans
Isoantibodies - metabolism
Kidney Allocation System
Kidney Transplantation
Male
Middle Aged
Renal
Tissue and Organ Procurement
Tissue Donors
Transplant
Transplant Recipients
United States
UNOS
Waiting Lists
Young Adult
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Summary:Abstract UNOS implemented a new kidney allocation system (New KAS) on December 4, 2014 with a primary goal of increasing equity to organ transplant for patients that were immunologically or socially disadvantaged by the previous allocation system (Previous KAS) that prioritized long wait times. We examined the effects of the New KAS on patients transplanted from the UCLA deceased donor waitlist during the first year and compared to the last year of the Previous KAS. The total number of deceased donor kidney transplants was increased in the New KAS as compared to the Previous KAS (178 vs 148). Transplant of regraft patients and of highly sensitized patients with cPRA ⩾99% was significantly increased in the New KAS (New KAS vs Previous KAS, 29.8% vs 11.5%, p ⩽0.0001, and 26.4% vs 2.7%, p ⩽0.0001, respectively). In the New KAS, the percentage of patient’s receiving allografts imported from outside our local area was also significantly increased (34.8% vs 15.5%, p
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2016.10.020