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Type of chromosome abnormality affects embryo morphology dynamics
Objective To study the differences in the cleavage time between types of embryo chromosomal abnormalities and elaborate algorithm to exclude aneuploid embryos according to the likelihood to be euploid. Design Retrospective cohort study. Setting University affiliated private center. Patient(s) Preimp...
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| Published in: | Fertility and sterility 2017-01, Vol.107 (1), p.229-235.e2 |
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| container_title | Fertility and sterility |
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| creator | Del Carmen Nogales, Maria, Ph.D Bronet, Fernando, Ph.D Basile, Natalia, Ph.D Martínez, Eva María, Ph.D Liñán, Alberto, Ph.D Rodrigo, Lorena, Ph.D Meseguer, Marcos, Ph.D |
| description | Objective To study the differences in the cleavage time between types of embryo chromosomal abnormalities and elaborate algorithm to exclude aneuploid embryos according to the likelihood to be euploid. Design Retrospective cohort study. Setting University affiliated private center. Patient(s) Preimplantational genetic screening patients (n = 112) including cases of advanced maternal age, repeated implantation failure, and recurrent miscarriage. A total of 485 embryos were analyzed. Intervention(s) None. Main Outcome Measure(s) All biopsied embryos were cultured in an incubator with time-lapse technology, cleavage timing from insemination to day 3 and all kinetic parameters that have been described in previous studies by our group. Result(s) Logistic regression analysis were used to identify morphokinetic parameters and some were strongly associated with complex aneuploid embryos; t3 (odds ratio = 0.590, 95% confidence interval 0.359–0.971) and t5–t2 (odds ratio = 0.151, 95% confidence interval 0.082–0.278). Conclusion(s) Embryo morphokinetics are affected by chromosome aneuploidy and further analysis of the chromosome content reveals higher differences when the complexity in the chromosome disorders is increased. The use of time-lapse monitoring, although not able to detect an abnormal embryo, may be potentially useful to discard those embryos with high risk of complex chromosomal abnormalities. |
| doi_str_mv | 10.1016/j.fertnstert.2016.09.019 |
| format | article |
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Design Retrospective cohort study. Setting University affiliated private center. Patient(s) Preimplantational genetic screening patients (n = 112) including cases of advanced maternal age, repeated implantation failure, and recurrent miscarriage. A total of 485 embryos were analyzed. Intervention(s) None. Main Outcome Measure(s) All biopsied embryos were cultured in an incubator with time-lapse technology, cleavage timing from insemination to day 3 and all kinetic parameters that have been described in previous studies by our group. Result(s) Logistic regression analysis were used to identify morphokinetic parameters and some were strongly associated with complex aneuploid embryos; t3 (odds ratio = 0.590, 95% confidence interval 0.359–0.971) and t5–t2 (odds ratio = 0.151, 95% confidence interval 0.082–0.278). Conclusion(s) Embryo morphokinetics are affected by chromosome aneuploidy and further analysis of the chromosome content reveals higher differences when the complexity in the chromosome disorders is increased. The use of time-lapse monitoring, although not able to detect an abnormal embryo, may be potentially useful to discard those embryos with high risk of complex chromosomal abnormalities.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2016.09.019</identifier><identifier>PMID: 27816230</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aneuploidy ; array CGH ; Biopsy ; Blastocyst - pathology ; Chromosome Aberrations ; Chromosome Disorders - diagnosis ; Chromosome Disorders - genetics ; Chromosome Disorders - pathology ; Chromosomes, Human ; Comparative Genomic Hybridization ; complex abnormalities ; Embryo kinetics ; Embryonic Development ; Female ; Fertilization in Vitro - adverse effects ; Genetic Testing ; Humans ; Internal Medicine ; Kinetics ; Logistic Models ; Microscopy, Video ; Obstetrics and Gynecology ; Odds Ratio ; Predictive Value of Tests ; Pregnancy ; Preimplantation Diagnosis - methods ; Retrospective Studies ; Risk Factors ; time lapse ; Time-Lapse Imaging - methods</subject><ispartof>Fertility and sterility, 2017-01, Vol.107 (1), p.229-235.e2</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2016 American Society for Reproductive Medicine</rights><rights>Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-91f1b52edbe40f5ae85ffd268d8c9cadb52359f5291cc39e6d6e8f9ee3170d7d3</citedby><cites>FETCH-LOGICAL-c479t-91f1b52edbe40f5ae85ffd268d8c9cadb52359f5291cc39e6d6e8f9ee3170d7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S001502821662839X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,786,790,3568,27957,27958,45815</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27816230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Del Carmen Nogales, Maria, Ph.D</creatorcontrib><creatorcontrib>Bronet, Fernando, Ph.D</creatorcontrib><creatorcontrib>Basile, Natalia, Ph.D</creatorcontrib><creatorcontrib>Martínez, Eva María, Ph.D</creatorcontrib><creatorcontrib>Liñán, Alberto, Ph.D</creatorcontrib><creatorcontrib>Rodrigo, Lorena, Ph.D</creatorcontrib><creatorcontrib>Meseguer, Marcos, Ph.D</creatorcontrib><title>Type of chromosome abnormality affects embryo morphology dynamics</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To study the differences in the cleavage time between types of embryo chromosomal abnormalities and elaborate algorithm to exclude aneuploid embryos according to the likelihood to be euploid. Design Retrospective cohort study. Setting University affiliated private center. Patient(s) Preimplantational genetic screening patients (n = 112) including cases of advanced maternal age, repeated implantation failure, and recurrent miscarriage. A total of 485 embryos were analyzed. Intervention(s) None. Main Outcome Measure(s) All biopsied embryos were cultured in an incubator with time-lapse technology, cleavage timing from insemination to day 3 and all kinetic parameters that have been described in previous studies by our group. Result(s) Logistic regression analysis were used to identify morphokinetic parameters and some were strongly associated with complex aneuploid embryos; t3 (odds ratio = 0.590, 95% confidence interval 0.359–0.971) and t5–t2 (odds ratio = 0.151, 95% confidence interval 0.082–0.278). Conclusion(s) Embryo morphokinetics are affected by chromosome aneuploidy and further analysis of the chromosome content reveals higher differences when the complexity in the chromosome disorders is increased. The use of time-lapse monitoring, although not able to detect an abnormal embryo, may be potentially useful to discard those embryos with high risk of complex chromosomal abnormalities.</description><subject>Adult</subject><subject>Aneuploidy</subject><subject>array CGH</subject><subject>Biopsy</subject><subject>Blastocyst - pathology</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Disorders - diagnosis</subject><subject>Chromosome Disorders - genetics</subject><subject>Chromosome Disorders - pathology</subject><subject>Chromosomes, Human</subject><subject>Comparative Genomic Hybridization</subject><subject>complex abnormalities</subject><subject>Embryo kinetics</subject><subject>Embryonic Development</subject><subject>Female</subject><subject>Fertilization in Vitro - adverse effects</subject><subject>Genetic Testing</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kinetics</subject><subject>Logistic Models</subject><subject>Microscopy, Video</subject><subject>Obstetrics and Gynecology</subject><subject>Odds Ratio</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Preimplantation Diagnosis - methods</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>time lapse</subject><subject>Time-Lapse Imaging - methods</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkU1rHDEMhk1paLZp_0KZYy4z9cfaY18KaUiTQKCHJJCb8dhy4u14vLFnA_Pv62WTFnrqRQLpfSX0CKGG4I5gIr5uOg95nspcY0drpcOqw0S9QyvCuWi54Ow9WmFMeIuppMfoYykbjLEgPf2AjmkviaAMr9DZ3bKFJvnGPuUUU0kRGjNMKUczhnlpjPdg59JAHPKSmpjy9imN6XFp3DKZGGz5hI68GQt8fs0n6P7Hxd35VXvz8_L6_Oymteteza0ingycghtgjT03ILn3jgrppFXWuNpjXHlOFbGWKRBOgPQKgJEeu96xE3R6mLvN6XkHZdYxFAvjaCZIu6KJZD2u7jWvUnmQ2pxKyeD1Nodo8qIJ1nuAeqP_AtR7gBorXQFW65fXLbshgvtjfCNWBd8PAqi3vgTIutgAkwUXciWlXQr_s-XbP0PsGKZgzfgLFiibtMtTZamJLlRjfbt_5P6PRAgqmXpgvwGCap3c</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Del Carmen Nogales, Maria, Ph.D</creator><creator>Bronet, Fernando, Ph.D</creator><creator>Basile, Natalia, Ph.D</creator><creator>Martínez, Eva María, Ph.D</creator><creator>Liñán, Alberto, Ph.D</creator><creator>Rodrigo, Lorena, Ph.D</creator><creator>Meseguer, Marcos, Ph.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>Type of chromosome abnormality affects embryo morphology dynamics</title><author>Del Carmen Nogales, Maria, Ph.D ; Bronet, Fernando, Ph.D ; Basile, Natalia, Ph.D ; Martínez, Eva María, Ph.D ; Liñán, Alberto, Ph.D ; Rodrigo, Lorena, Ph.D ; Meseguer, Marcos, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-91f1b52edbe40f5ae85ffd268d8c9cadb52359f5291cc39e6d6e8f9ee3170d7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aneuploidy</topic><topic>array CGH</topic><topic>Biopsy</topic><topic>Blastocyst - pathology</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Disorders - diagnosis</topic><topic>Chromosome Disorders - genetics</topic><topic>Chromosome Disorders - pathology</topic><topic>Chromosomes, Human</topic><topic>Comparative Genomic Hybridization</topic><topic>complex abnormalities</topic><topic>Embryo kinetics</topic><topic>Embryonic Development</topic><topic>Female</topic><topic>Fertilization in Vitro - adverse effects</topic><topic>Genetic Testing</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kinetics</topic><topic>Logistic Models</topic><topic>Microscopy, Video</topic><topic>Obstetrics and Gynecology</topic><topic>Odds Ratio</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Preimplantation Diagnosis - methods</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>time lapse</topic><topic>Time-Lapse Imaging - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Del Carmen Nogales, Maria, Ph.D</creatorcontrib><creatorcontrib>Bronet, Fernando, Ph.D</creatorcontrib><creatorcontrib>Basile, Natalia, Ph.D</creatorcontrib><creatorcontrib>Martínez, Eva María, Ph.D</creatorcontrib><creatorcontrib>Liñán, Alberto, Ph.D</creatorcontrib><creatorcontrib>Rodrigo, Lorena, Ph.D</creatorcontrib><creatorcontrib>Meseguer, Marcos, Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Del Carmen Nogales, Maria, Ph.D</au><au>Bronet, Fernando, Ph.D</au><au>Basile, Natalia, Ph.D</au><au>Martínez, Eva María, Ph.D</au><au>Liñán, Alberto, Ph.D</au><au>Rodrigo, Lorena, Ph.D</au><au>Meseguer, Marcos, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type of chromosome abnormality affects embryo morphology dynamics</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>107</volume><issue>1</issue><spage>229</spage><epage>235.e2</epage><pages>229-235.e2</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objective To study the differences in the cleavage time between types of embryo chromosomal abnormalities and elaborate algorithm to exclude aneuploid embryos according to the likelihood to be euploid. Design Retrospective cohort study. Setting University affiliated private center. Patient(s) Preimplantational genetic screening patients (n = 112) including cases of advanced maternal age, repeated implantation failure, and recurrent miscarriage. A total of 485 embryos were analyzed. Intervention(s) None. Main Outcome Measure(s) All biopsied embryos were cultured in an incubator with time-lapse technology, cleavage timing from insemination to day 3 and all kinetic parameters that have been described in previous studies by our group. Result(s) Logistic regression analysis were used to identify morphokinetic parameters and some were strongly associated with complex aneuploid embryos; t3 (odds ratio = 0.590, 95% confidence interval 0.359–0.971) and t5–t2 (odds ratio = 0.151, 95% confidence interval 0.082–0.278). Conclusion(s) Embryo morphokinetics are affected by chromosome aneuploidy and further analysis of the chromosome content reveals higher differences when the complexity in the chromosome disorders is increased. The use of time-lapse monitoring, although not able to detect an abnormal embryo, may be potentially useful to discard those embryos with high risk of complex chromosomal abnormalities.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27816230</pmid><doi>10.1016/j.fertnstert.2016.09.019</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 2017-01, Vol.107 (1), p.229-235.e2 |
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| source | ScienceDirect Journals |
| subjects | Adult Aneuploidy array CGH Biopsy Blastocyst - pathology Chromosome Aberrations Chromosome Disorders - diagnosis Chromosome Disorders - genetics Chromosome Disorders - pathology Chromosomes, Human Comparative Genomic Hybridization complex abnormalities Embryo kinetics Embryonic Development Female Fertilization in Vitro - adverse effects Genetic Testing Humans Internal Medicine Kinetics Logistic Models Microscopy, Video Obstetrics and Gynecology Odds Ratio Predictive Value of Tests Pregnancy Preimplantation Diagnosis - methods Retrospective Studies Risk Factors time lapse Time-Lapse Imaging - methods |
| title | Type of chromosome abnormality affects embryo morphology dynamics |
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