The prognostic implication of the expression of EGFR, p53, cyclin D1, Bcl-2 and p16 in primary locally advanced oral squamous cell carcinoma cases: a tissue microarray study

Oral squamous cell carcinomas comprise a heterogeneous tumor cell population with varied molecular characteristics, which makes prognostication of these tumors a complex and challenging issue. Thus, molecular profiling of these tumors is advantageous for an accurate prognostication and treatment pla...

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Published in:Medical oncology (Northwood, London, England) London, England), 2016-12, Vol.33 (12), p.138-138, Article 138
Main Authors: Solomon, Monica Charlotte, Vidyasagar, M. S., Fernandes, Donald, Guddattu, Vasudev, Mathew, Mary, Shergill, Ankur Kaur, Carnelio, Sunitha, Chandrashekar, Chetana
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - radiotherapy
Cohort Studies
Cyclin D1 - biosynthesis
Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis
ErbB Receptors - biosynthesis
Female
Head and Neck Neoplasms - drug therapy
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - pathology
Head and Neck Neoplasms - radiotherapy
Hematology
Humans
Immunohistochemistry
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Mouth Neoplasms - drug therapy
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Mouth Neoplasms - radiotherapy
Neoplasm Proteins - biosynthesis
Oncology
Original Paper
Pathology
Prognosis
Proto-Oncogene Proteins c-bcl-2 - biosynthesis
Squamous Cell Carcinoma of Head and Neck
Tissue Array Analysis
Treatment Outcome
Tumor Suppressor Protein p53 - biosynthesis
Young Adult
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Summary:Oral squamous cell carcinomas comprise a heterogeneous tumor cell population with varied molecular characteristics, which makes prognostication of these tumors a complex and challenging issue. Thus, molecular profiling of these tumors is advantageous for an accurate prognostication and treatment planning. This is a retrospective study on a cohort of primary locally advanced oral squamous cell carcinomas ( n  = 178) of an Indian rural population. The expression of EGFR, p53, cyclin D1, Bcl-2 and p16 in a cohort of primary locally advanced oral squamous cell carcinomas was evaluated. A potential biomarker that can predict the tumor response to treatment was identified. Formalin-fixed paraffin-embedded tumor blocks of ( n  = 178) of histopathologically diagnosed cases of locally advanced oral squamous cell carcinomas were selected. Tissue microarray blocks were constructed with 2 cores of 2 mm diameter from each tumor block. Four-micron-thick sections were cut from these tissue microarray blocks. These tissue microarray sections were immunohistochemically stained for EGFR, p53, Bcl-2, cyclin D1 and p16. In this cohort, EGFR was the most frequently expressed 150/178 (84%) biomarker of the cases. Kaplan–Meier analysis showed a significant association ( p  = 0.038) between expression of p53 and a poor prognosis. A Poisson regression analysis showed that tumors that expressed p53 had a two times greater chance of recurrence (unadjusted IRR—95% CI 2.08 (1.03, 4.5), adjusted IRR—2.29 (1.08, 4.8) compared with the tumors that did not express this biomarker. Molecular profiling of oral squamous cell carcinomas will enable us to categorize our patients into more realistic risk groups. With biologically guided tumor characterization, personalized treatment protocols can be designed for individual patients, which will improve the quality of life of these patients.
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-016-0851-8