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Differences in humoral immune response between patients with or without nasal carriage of Staphylococcus aureus
The humoral immune response against 43 staphylococcal antigens was compared among hospitalized patients where none of them had any staphylococcal infection on the day of admission with or without nasal Staphylococcus aureus carriage. Fifty-nine carriers and 59 matched non-carriers were studied. The...
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Published in: | European journal of clinical microbiology & infectious diseases 2017-03, Vol.36 (3), p.451-458 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The humoral immune response against 43 staphylococcal antigens was compared among hospitalized patients where none of them had any staphylococcal infection on the day of admission with or without nasal
Staphylococcus aureus
carriage. Fifty-nine carriers and 59 matched non-carriers were studied. The carriers harbored
S. aureus
of 35 different
spa
types, including three t037/ST239 methicillin-resistant
S. aureus
(MRSA) (5.1%). Among the 118 patients, 31 acquired
S. aureus
during hospitalization. In colonized and non-colonized patients, unique patterns of
S. aureus
-specific immune responses were observed. The mean fluorescence indices (MFIs) of antibodies against 36/43 (83.7%) antigens were seen to be elevated among carriers. The MFI among carriers with acquisition was significantly higher for staphylococcal superantigen-like protein 5 (SSL5,
p
= 0.028) when compared to carriers without acquisition. High antibody levels against staphylococcal enterotoxin A (SEA) among carriers illustrate its role as a superantigen in both infection and colonization. We also report a dynamic immune response in
S. aureus
-carrying patients against the recently reported formyl peptide receptor-like inhibitory (FLIPr)-like protein. In the current study, the dynamics of antibodies against staphylococcal antigens among carrier patients seem quite similar to non-carrier patients. To better understand the dynamic immunogenicity during
S. aureus
infection and colonization, artificial colonization studies and investigation of the changes in the levels of antibodies against other staphylococcal antigens are recommended. |
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ISSN: | 0934-9723 1435-4373 |
DOI: | 10.1007/s10096-016-2817-3 |