Interleukin-1beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells

This study reports that in Schwann cell tissue culture the administration of the two pro-inflammatory cytokines, interleukin-1beta (IL-1β) and interferon-gamma (IFN-γ), at different dosages, singly or in combination, can induce apoptosis and/or mitosis. Schwann cell apoptosis was maximal within 24 h...

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Bibliographic Details
Published in:Journal of neuroimmunology 2002-03, Vol.124 (1), p.29-35
Main Authors: Conti, Giancarlo, De Pol, Anto, Scarpini, Elio, Vaccina, Fabiana, De Riz, Milena, Baron, PierLuigi, Tiriticco, Marco, Scarlato, Guglielmo
Format: Article
Language:English
Subjects:
Apoptosis
Demyelination
Interferon-gamma
Interleukin-1beta
Peripheral nerve
Schwann cell
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Summary:This study reports that in Schwann cell tissue culture the administration of the two pro-inflammatory cytokines, interleukin-1beta (IL-1β) and interferon-gamma (IFN-γ), at different dosages, singly or in combination, can induce apoptosis and/or mitosis. Schwann cell apoptosis was maximal within 24 h of stimulation with 50 U/ml of IFN-γ, while proliferation was at its peak within 24 h with 10 U/ml IL-1β, and both processes decreased progressively by 48 and 72 h. Moreover, the combination of the two cytokines did not show any synergistic effect. These data can be interpreted as a possible involvement of pro-inflammatory cytokines not only in myelin disruption but also in promoting remyelination.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(02)00003-6