Significance of Time-Zero Biopsy for Graft Renal Function After Deceased Donor Kidney Transplantation

Abstract Background Donor organ quality from deceased donors affects graft survival after kidney transplantation. This study was performed to identify clinico-histological factors that affect early graft outcome, using time-zero biopsies of deceased donors. Methods Between December 2006 and July 201...

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Bibliographic Details
Published in:	Transplantation proceedings 2016-10, Vol.48 (8), p.2656-2662
Main Authors:	Lee, A.L, Huh, K.H, Lee, S.H, Lee, J.J, Joo, D.J, Jeong, H.J, Kim, M.S, Kim, S.I, Kim, Y.S
Format:	Article
Language:	eng
Subjects:	Adult Aged Biopsy Female Graft Survival Humans Kidney - pathology Kidney Transplantation - mortality Male Middle Aged Surgery Tissue Donors Transplants - pathology Treatment Outcome
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Summary:	Abstract Background Donor organ quality from deceased donors affects graft survival after kidney transplantation. This study was performed to identify clinico-histological factors that affect early graft outcome, using time-zero biopsies of deceased donors. Methods Between December 2006 and July 2011, 135 recipients of deceased donor kidneys were included, and data concerning donor and recipient-related clinical characteristics and histological findings of time-zero biopsies categorized by use of the Banff 07 scoring system were included in the analysis. Mean donor age was 44.3 ± 12.3 years. Mean terminal serum creatinine level and cold ischemic time were 1.50 ± 0.96 mg/dL and 349 ± 166 minutes. Mean follow-up time after transplantation was 37 ± 16 months, and all recipients were followed for at least 1 year. Results Global glomerulosclerosis (38.5%), tubular atrophy (37.8%), arteriolar hyaline thickening (25.9%), interstitial fibrosis (23%), vascular fibrous intimal thickening (21.5%), and interstitial inflammation (20%) were the major pathologic findings of time-zero biopsies. The majority of pathologic scores were of mild degree. Among histological findings, arteriolar hyaline thickening and interstitial fibrosis were only significantly associated with early post-transplant renal function in multivariate analyses. Conclusions Considerations of clinico-histological findings were found to be valuable for predicting early graft outcome after deceased donor kidney transplantation.
ISSN:	0041-1345 1873-2623