Drug interaction between erlotinib and phenytoin for brain metastases in a patient with nonsmall cell lung cancer

Highlights • The phenytoin blood concentration increased by erlotinib co-administration. • The erlotinib blood concentration increased after the stoppage of phenytoin. • It is important to avoid enzyme-inducing antiepileptic drugs when erlotinib is used.

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-11, Vol.101, p.9-10
Main Authors: Ohgami, Masahiro, Kaburagi, Takayuki, Kurosawa, Atsuhiko, Homma, Masato
Format: Article
Language:English
Subjects:
Brain - pathology
Brain Neoplasms - complications
Brain Neoplasms - drug therapy
Brain Neoplasms - secondary
Carcinoma, Non-Small-Cell Lung - complications
Carcinoma, Non-Small-Cell Lung - drug therapy
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Cytochrome P-450 CYP1A2 Inducers - blood
Cytochrome P-450 CYP1A2 Inducers - therapeutic use
Cytochrome P-450 CYP3A - metabolism
Drug Interactions
Drug-drug interaction
Erlotinib
Erlotinib Hydrochloride - blood
Erlotinib Hydrochloride - therapeutic use
Female
Hematology, Oncology and Palliative Medicine
Humans
Lung Neoplasms - pathology
Middle Aged
Phenytoin
Phenytoin - adverse effects
Phenytoin - blood
Phenytoin - therapeutic use
Protein Kinase Inhibitors - adverse effects
Protein Kinase Inhibitors - therapeutic use
Pulmonary/Respiratory
Receptor, Epidermal Growth Factor - antagonists & inhibitors
Seizures - drug therapy
Seizures - etiology
Treatment Outcome
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Description
Summary:Highlights • The phenytoin blood concentration increased by erlotinib co-administration. • The erlotinib blood concentration increased after the stoppage of phenytoin. • It is important to avoid enzyme-inducing antiepileptic drugs when erlotinib is used.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2016.08.009