Thrombotic issues in transgender medicine: A review

Clinicians, including hematologists, are more frequently encountering transgender individuals in practice; however, most lack training on the management and complications of transgender medicine. Hormonal therapy forms the backbone of medical interventions for patients undergoing gender transition....

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Bibliographic Details
Published in:American journal of hematology 2017-02, Vol.92 (2), p.204-208
Main Authors: Shatzel, Joseph J., Connelly, Kara J., DeLoughery, Thomas G.
Format: Article
Language:English
Subjects:
Female
Health Services for Transgender Persons
Hematology
Hormone Replacement Therapy - adverse effects
Hormone Replacement Therapy - methods
Humans
Incidence
Male
Transgender Persons
Venous Thrombosis - epidemiology
Venous Thrombosis - etiology
Venous Thrombosis - therapy
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Summary:Clinicians, including hematologists, are more frequently encountering transgender individuals in practice; however, most lack training on the management and complications of transgender medicine. Hormonal therapy forms the backbone of medical interventions for patients undergoing gender transition. While supplementing an individual's intrinsic sex hormone is associated with a variety of hematologic complications including increased rates of venous thrombosis, cardiovascular events, erthyrocytosis, and malignancy, the risks of supplementing with opposing sex hormones are not well understood. Data on the hematologic complications of these therapies are accumulating but remain limited, and clinicians have little experience with their management. This review highlights the current interventions available in transgender medicine and related potential hematologic complications, and it suggests simple, evidence‐based management going forward. Am. J. Hematol. 92:204–208, 2017. © 2016 Wiley Periodicals, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.24593