Chiral separation and determination of ketamine and norketamine in hair by capillary electrophoresis

Highlights • Original CZE enantioselective method to determine ketamine and norketamine in hair. • Chiral separation of ketamine (R = 2.4) and norketamine (R = 2.0) in less than 10 min. • Powerful tool to investigate chronic exposure to/abuse of ketamine. • Useful in clinical and forensic contexts,...

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Bibliographic Details
Published in:Forensic science international 2016-09, Vol.266, p.304-310
Main Authors: Porpiglia, Nadia, Musile, Giacomo, Bortolotti, Federica, Palo, Elio Franco De, Tagliaro, Franco
Format: Article
Language:English
Subjects:
Analytical methods
Calibration
Capillary electrophoresis
Capillary zone
Chiral separation
Colleges & universities
Drug abuse
Drug dosages
Drugs
Electrokinetics
Electrophoresis
Enantiomers
Forensic sciences
Forensic toxicology
Hair
Hair analysis
Industrial safety
Ketamine
Laboratories
Linearity
Liquid-liquid extraction
Metabolism
Metabolites
Methods
Norketamine
Pathology
Pharmacodynamics
Pharmacology
Phosphates
Recovery
Regression
Regression analysis
Regression coefficients
Separation
Urine
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Summary:Highlights • Original CZE enantioselective method to determine ketamine and norketamine in hair. • Chiral separation of ketamine (R = 2.4) and norketamine (R = 2.0) in less than 10 min. • Powerful tool to investigate chronic exposure to/abuse of ketamine. • Useful in clinical and forensic contexts, and in traffic and workplace toxicology. • The method applied to authentic samples shows high throughput and negligible costs.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2016.06.017