One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

A convenient and environmentally attractive one-pot two-step process for the synthesis of beta -adrenergic blockers via Shi's organocatalytic epoxidation of terminal alkenes and subsequent aminolysis reaction of epoxides with isopropylamine under mild reaction conditions has been developed.

Saved in:
Bibliographic Details
Published in:RSC advances 2014-01, Vol.4 (62), p.32796-32801
Main Authors: Held, Felix E., Wei, Shengwei, Eder, Kathrin, Tsogoeva, Svetlana B.
Format: Article
Language:English
Subjects:
Alkenes
Epoxidation
Synthesis (chemistry)
Terminals
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A convenient and environmentally attractive one-pot two-step process for the synthesis of beta -adrenergic blockers via Shi's organocatalytic epoxidation of terminal alkenes and subsequent aminolysis reaction of epoxides with isopropylamine under mild reaction conditions has been developed.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA04011B