Comparative study on driver mutations in primary and metastatic melanomas at a single Japanese institute: A clue for intra- and inter-tumor heterogeneity

Highlights • In the present paper, we analyzed driver mutations of 77 melanoma tissue samples from 60 patients. • We focused on the intra-tumor mutational　heterogeneity in the primary melanoma. • Furthermore, we focused on the inter-tumor mutational heterogeneity between the primary and metastatic m...

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Bibliographic Details
Published in:Journal of dermatological science 2017-01, Vol.85 (1), p.51-57
Main Authors: Kaji, Tatsuya, Yamasaki, Osamu, Takata, Minoru, Otsuka, Masaki, Hamada, Toshihisa, Morizane, Shin, Asagoe, Kenji, Yanai, Hiroyuki, Hirai, Yoji, Umemura, Hiroshi, Iwatsuki, Keiji
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
BRAF
Dermatology
DNA Mutational Analysis
Driver mutation
Female
Genetic Heterogeneity
Humans
Japan
Male
Melanoma
Melanoma - genetics
Melanoma - pathology
Melanoma - secondary
Metastasis
Middle Aged
Mutation
Mutational heterogeneity
Neoplasms, Unknown Primary - genetics
Oncogenes - genetics
Primary
Proto-Oncogene Proteins B-raf - genetics
Young Adult
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Summary:Highlights • In the present paper, we analyzed driver mutations of 77 melanoma tissue samples from 60 patients. • We focused on the intra-tumor mutational　heterogeneity in the primary melanoma. • Furthermore, we focused on the inter-tumor mutational heterogeneity between the primary and metastatic melanomas.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2016.10.006