Adipokine Pattern After Bariatric Surgery: Beyond the Weight Loss

Besides the role in energy storing and body health isolating, adipose tissue produces proteins, the so-called adipokines, with pro-inflammatory or anti-inflammatory actions that contribute to metabolic control and to appetite and energy expenditure regulation. The marked adipose tissue loss followin...

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Bibliographic Details
Published in:Obesity Surgery 2016-11, Vol.26 (11), p.2793-2801
Main Authors: Adami, Gian Franco, Scopinaro, Nicola, Cordera, Renzo
Format: Article
Language:English
Subjects:
Adipokines - blood
Adipose Tissue - metabolism
Bariatric Surgery - rehabilitation
Humans
Inflammation - blood
Inflammation - complications
Insulin Resistance - physiology
Medicine
Medicine & Public Health
Obesity, Morbid - complications
Obesity, Morbid - metabolism
Obesity, Morbid - rehabilitation
Obesity, Morbid - surgery
Review Article
Surgery
Tissues
Weight control
Weight Loss
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Summary:Besides the role in energy storing and body health isolating, adipose tissue produces proteins, the so-called adipokines, with pro-inflammatory or anti-inflammatory actions that contribute to metabolic control and to appetite and energy expenditure regulation. The marked adipose tissue loss following bariatric surgery corresponds to a rearrangement of serum adipokine pattern, with increase of anti-inflammatory and decrease of pro-inflammatory agents. This might play a relevant role in the postoperative improvement of metabolic conditions. However, after surgically induced weight loss, other investigations failed to evidence significant modifications of serum concentration of some adipokines. This review speculates that the composition of adipose tissue lost could influence postoperative changes in some adipokine concentration and that an adequate adipokine pattern plays a pivotal role for the long-term metabolic outcome.
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-016-2347-1