Metals in Alzheimer’s and Parkinson’s Disease: Relevance to Dementia with Lewy Bodies

Despite being a common form of dementia, dementia with Lewy bodies is relatively under-researched when compared with Parkinson’s disease and Alzheimer’s disease. This has arisen from the fact that dementia with Lewy bodies has been historically difficult to diagnose resulting in a lack of well-defin...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2016-11, Vol.60 (3), p.279-288
Main Authors: McAllum, Erin J., Finkelstein, David I.
Format: Article
Language:English
Subjects:
Alzheimer Disease - complications
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Humans
Lewy Body Disease - complications
Lewy Body Disease - drug therapy
Lewy Body Disease - metabolism
Metals - metabolism
Neurochemistry
Neurology
Neurosciences
Oxidative Stress
Proteomics
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Summary:Despite being a common form of dementia, dementia with Lewy bodies is relatively under-researched when compared with Parkinson’s disease and Alzheimer’s disease. This has arisen from the fact that dementia with Lewy bodies has been historically difficult to diagnose resulting in a lack of well-defined clinical cohorts and post-mortem tissue available for scientific research. Dementia with Lewy bodies shares clinical and pathological features with both Parkinson’s disease and Alzheimer’s disease so it is therefore likely that it also has similar pathogenic mechanisms leading to disease. This review will discuss the role of biological metals in Parkinson’s disease and Alzheimer’s disease and whether there are indications that metals may also be involved in dementia with Lewy bodies.
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-016-0809-5