Serum level of neopterin is not a marker of disease activity in treated rheumatoid arthritis patients

Neopterin has been measured in many autoimmune diseases and was reported as a marker of cellular immunity activation in rheumatoid asthritis (RA). The aim of this work was to assess serum neopterin as a marker of disease activity in treated RA patients. We measured serum level of neopterin in 120 tr...

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Bibliographic Details
Published in:Clinical rheumatology 2017-09, Vol.36 (9), p.1975-1979
Main Authors: El-Lebedy, Dalia, Hussein, Jihan, Ashmawy, Ingy, Mohammed, Asmaa M.
Format: Article
Language:English
Subjects:
Autoimmune diseases
Cell-mediated immunity
Disease
Health risk assessment
High-performance liquid chromatography
Medicine
Medicine & Public Health
Neopterin
Original Article
Rheumatoid arthritis
Rheumatology
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Summary:Neopterin has been measured in many autoimmune diseases and was reported as a marker of cellular immunity activation in rheumatoid asthritis (RA). The aim of this work was to assess serum neopterin as a marker of disease activity in treated RA patients. We measured serum level of neopterin in 120 treated RA patients and 100 age- and sex-matched controls by high-performance liquid chromatography (HPLC) method, and disease activity score was calculated in all patients by DAS28-CRP score. Significantly higher levels of neopterin were observed in RA patients (11.46 ± 3.56 nmol/L) compared to healthy controls (4.74 ± 1.98 nmol/L), P  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-016-3433-4