Promotion of enamel caries remineralization by an amelogenin-derived peptide in a rat model

Highlights • A novel peptide based on amelogenin had been confirmed to promote remineralization in an in vitro pH-cycling model. • A classic animal caries model was adopted to explore whether this peptide has same effects in vivo. • This amelogenin-based peptide can promote remineralization in rat c...

Full description

Saved in:
Bibliographic Details
Published in:Archives of oral biology 2017-01, Vol.73, p.66-71
Main Authors: Han, Sili, Fan, Yingying, Zhou, Zhengli, Tu, Huanxin, Li, Danxue, Lv, Xueping, Ding, Longjiang, Zhang, Linglin
Format: Article
Language:English
Subjects:
Advanced Basic Science
Amelogenin
Amelogenin - pharmacology
Animals
Caries
Cariostatic Agents - pharmacology
Dental Caries - pathology
Dentistry
Disease Models, Animal
Hydrogen-Ion Concentration
In Vitro Techniques
In vivo model
Microscopy, Polarization
Minerals - metabolism
Peptide
Peptides - pharmacology
Random Allocation
Rat
Rats
Rats, Sprague-Dawley
Remineralization
Sodium Fluoride - pharmacology
Streptococcus mutans
Tooth Remineralization - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • A novel peptide based on amelogenin had been confirmed to promote remineralization in an in vitro pH-cycling model. • A classic animal caries model was adopted to explore whether this peptide has same effects in vivo. • This amelogenin-based peptide can promote remineralization in rat caries model. • This peptide shows strong potential for treating enamel caries in clinic.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2016.09.009