Low transferrin saturation is associated with impaired fasting glucose and insulin resistance in the South Korean adults: the 2010 Korean National Health and Nutrition Examination Survey

Aims The associations of transferrin saturation with diabetes have not been well evaluated and conflicting results have been reported. The purpose of this study is to examine the association of iron indices (serum ferritin and transferrin saturation) with risk of impaired fasting glucose and insulin...

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Bibliographic Details
Published in:Diabetic medicine 2015-05, Vol.32 (5), p.673-678
Main Authors: Park, R. J., Moon, J. D.
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group - ethnology
Blood Glucose - metabolism
Cross-Sectional Studies
Diabetes
Fasting - metabolism
Female
Ferritins - metabolism
Health Surveys
Humans
Insulin - blood
Insulin resistance
Insulin Resistance - ethnology
Insulin Resistance - physiology
Male
Middle Aged
Republic of Korea
Risk Factors
Transferrin - metabolism
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Summary:Aims The associations of transferrin saturation with diabetes have not been well evaluated and conflicting results have been reported. The purpose of this study is to examine the association of iron indices (serum ferritin and transferrin saturation) with risk of impaired fasting glucose and insulin resistance. Methods We conducted a cross‐sectional study in 2413 individuals (1150 men and 1263 women) aged 20–50 years who participated in the 2010 Korean National Health and Nutrition Examination Survey. Participants were free of diabetes, malignancy, liver cirrhosis, chronic renal failure, anaemia, pregnancy and menopause. Fasting plasma glucose, insulin and the homeostasis model assessment of insulin resistance (HOMA–IR) were measured as the outcomes. Results Impaired fasting glucose was more prevalent in the highest compared with the lowest serum ferritin quartile among men (odds ratio [OR], 1.97; 95% confidence interval [CI], 1.20–3.24) after adjustment for multiple covariates. Following the same adjustment, impaired fasting glucose was less prevalent in the highest compared with the lowest transferrin saturation quartile among men (OR, 0.45; 95% CI, 0.25–0.80) and women (OR, 0.33; 95% CI, 0.14–0.77). Moreover, a higher ferritin level was significantly associated with higher HOMA–IR after adjusting for confounders in men. Lower transferrin saturation was also significantly associated with higher insulin levels and HOMA–IR in both sexes. Conclusions Lower transferrin saturations were associated with an increased risk of impaired fasting glucose and insulin resistance among general South Korean population. What's new? The associations of iron indices (serum ferritin and transferrin saturation) with impaired fasting glucose and insulin resistance were examined. Study participants included 2413 Korean individuals aged 20–50 years. Lower transferrin saturations were associated with an increased risk of impaired fasting glucose and insulin resistance.
ISSN:0742-3071
1464-5491
DOI:10.1111/dme.12643