Hazelnut Allergens: Molecular Characterization, Detection, and Clinical Relevance

In last few years, special attention has been given to food-induced allergies, in which hazelnut allergy is highlighted. Hazelnut is one of the most commonly consumed tree nuts, being largely used by the food industry in a variety of processed foods. It has been regarded as a food with potential hea...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2016-11, Vol.56 (15), p.2579-2605
Main Authors: Costa, Joana, Mafra, Isabel, Carrapatoso, Isabel, Oliveira, Maria Beatriz P. P.
Format: Article
Language:English
Subjects:
Antigens, Plant - analysis
Antigens, Plant - genetics
Antigens, Plant - immunology
Biosensing Techniques
Corylus
Corylus - immunology
Corylus avellana L
detection
DNA - analysis
Enzyme-Linked Immunosorbent Assay
Food allergens
Food allergies
Food Analysis - methods
Food science
hazelnut allergy
Humans
Nut Hypersensitivity - epidemiology
Nut Hypersensitivity - immunology
Nut Hypersensitivity - prevention & control
Nuts
Plant Proteins - analysis
Plant Proteins - chemistry
Plant Proteins - immunology
Polymerase Chain Reaction
prevalence
threshold levels
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Summary:In last few years, special attention has been given to food-induced allergies, in which hazelnut allergy is highlighted. Hazelnut is one of the most commonly consumed tree nuts, being largely used by the food industry in a variety of processed foods. It has been regarded as a food with potential health benefits, but also as a source of allergens capable of inducing mild to severe allergic reactions in sensitized individuals. Considering the great number of reports addressing hazelnut allergens, with an estimated increasing trend, this review intends to assemble all the relevant information available so far on the following main issues: prevalence of tree nut allergy, clinical threshold levels, molecular characterization of hazelnut allergens (Cor a 1, Cor a 2, Cor a 8, Cor a 9, Cor a 10, Cor a 11, Cor a 12, Cor a 14, and Cor a TLP) and their clinical relevance, and methodologies for detection of hazelnut allergens in foods. A comprehensive overview of the current data about the molecular characterization of hazelnut allergens is presented, relating to biochemical classification and biological function with clinical importance. Recent advances in hazelnut allergen detection methodologies are summarized and compared, including all the novel protein-based and DNA-based approaches.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2013.826173