Bovine dopamine receptors DRD1, DRD4, and DRD5: genetic polymorphisms and diversities among ten cattle breeds

The aim of this study was to analyze the allelic frequency distribution and segregation among breeds and/or between different cattle genetic groups of four novel single nucleotide polymorphisms of the bovine DRD1 and DRD5 genes and one reported SNP from the DRD4 gene. One hundred and nine-animals fr...

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Bibliographic Details
Published in:Genetics and molecular research 2016-01, Vol.15 (1)
Main Authors: Sifuentes-Rincón, A M, Trejo-Tapia, A G, Randel, R D, Ambriz-Morales, P, Parra-Bracamonte, G M
Format: Article
Language:English
Subjects:
Alleles
Animals
Behavior, Animal
Bos taurus
Breeding
Cattle
Female
Gene Frequency
Genotype
Male
Phenotype
Polymorphism, Single Nucleotide
Principal Component Analysis
Protein Isoforms - genetics
Quantitative Trait, Heritable
Receptors, Dopamine - genetics
Temperament
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Summary:The aim of this study was to analyze the allelic frequency distribution and segregation among breeds and/or between different cattle genetic groups of four novel single nucleotide polymorphisms of the bovine DRD1 and DRD5 genes and one reported SNP from the DRD4 gene. One hundred and nine-animals from ten different cattle breeds were genotyped and allelic frequencies for each locus were estimated. There were significant differences in the allelic frequencies (P < 0.05) among breeds for the DRD1 and DRD5 markers. The allelic frequencies for markers DRD1-825A>G and DRD5-378C>T were also significantly different between groups differing in genetic background. Because differences in temperament have been reported between Bos taurus taurus and B. taurus indicus breeds and their crosses, further studies are needed to investigate if any association exists between described markers and cattle behavior traits.
ISSN:1676-5680
1676-5680
DOI:10.4238/gmr.15017725