Distribution of EGFR Mutations in 10,607 Russian Patients with Lung Cancer

Introduction This study was aimed to evaluate distribution of epidermal growth factor receptor (EGFR) mutations in a large series of Russian lung cancer (LC) patients. Methods 10,607 LC samples were considered for EGFR analysis; EGFR status was successfully determined in 10,426 cases (98.3 %), indic...

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Bibliographic Details
Published in:Molecular diagnosis & therapy 2016-08, Vol.20 (4), p.401-406
Main Authors: Imyanitov, Evgeny N., Demidova, Irina A., Gordiev, Marat G., Filipenko, Maxim L., Kekeyeva, Tatyana V., Moliaka, Yuri K., Gervas, Polina A., Kozhemyako, Valeriy B., Vodolazhskiy, Dmitriy I., Sergeyeva, Liubov A., Fattakhova, Dinara U., Iyevleva, Aglaya G., Mitiushkina, Natalia V., Kuligina, Ekatherina Sh, Barinov, Alexey A., Mommaeva, Meriiam S., Aleksakhina, Svetlana N., Tsimafeyeu, Ilya V., Tjulandin, Sergey A.
Format: Article
Language:English
Subjects:
Age
Biomedical and Life Sciences
Biomedicine
Cancer Research
Ethics
Females
Gender
Histology
Human Genetics
Internet resources
Laboratory Medicine
Lung cancer
Molecular Medicine
Mortality
Multivariate analysis
Mutation
Original Research Article
Patients
Pharmacotherapy
Smoking
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Summary:Introduction This study was aimed to evaluate distribution of epidermal growth factor receptor (EGFR) mutations in a large series of Russian lung cancer (LC) patients. Methods 10,607 LC samples were considered for EGFR analysis; EGFR status was successfully determined in 10,426 cases (98.3 %), indicating relatively low failure rate. Results EGFR mutations (ex19del and L858R) were detected in 1759/8716 (20.2 %) adenocarcinomas, 28/669 (4.2 %) squamous cell carcinomas (SCC) and 8/119 (6.7 %) large cell carcinomas. The occurrence of EGFR mutations in adenocarcinomas gradually increased with age, being attributed mainly to the increment of the L858R frequency in non-smokers (patients aged 18–30 years: 1/27 (3.7 %); 31–40 years: 5/98 (5.1 %); 41–50 years: 18/276 (6.5 %); 51–60 years: 102/944 (10.8 %); 61–70 years: 138/1011 (13.7 %); 71–80 years: 85/496 (17.1 %); 81–100 years: 5/27 (18.5 %); p  
ISSN:1177-1062
1179-2000
DOI:10.1007/s40291-016-0213-4