POLLUTION BY METALS: IS THERE A RELATIONSHIP IN GLYCEMIC CONTROL?

Abstract There are evidences of environmental pollution and health effects. Metals are pollutants implicated in systemic toxicity. One of the least studied effects, but which is currently becoming more important, is the effect of metals on glycemic control. Metals have been implicated as causes of c...

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Published in:Environmental toxicology and pharmacology 2016-09, Vol.46, p.337-343
Main Authors: González-Villalva, Adriana, MD, PhD, Colín-Barenque, Laura, PhD, Patricia, Bizarro-Nevares, MSc, Rojas-Lemus, Marcela, PhD, Rodríguez-Lara, Vianey, PhD, Isabel, García-Pelaez, PhD, Ustarroz-Cano, Martha, PhD, López-Valdéz, Nelly, MSc, Albarrán-Alonso, Juan Carlos, Fortoul, Teresa I
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Diabetes
Emergency
Environmental Pollutants - toxicity
Humans
Hyperglycemia
Hyperglycemia - chemically induced
Hyperglycemia - metabolism
Hypoglycemia
Hypoglycemia - chemically induced
Hypoglycemia - metabolism
Insulin
Insulin - blood
Insulin Resistance
Metals
Metals - toxicity
Pollution
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Summary:Abstract There are evidences of environmental pollution and health effects. Metals are pollutants implicated in systemic toxicity. One of the least studied effects, but which is currently becoming more important, is the effect of metals on glycemic control. Metals have been implicated as causes of chronic inflammation and oxidative stress and are associated to obesity, hyperglycemia and even diabetes. Arsenic, iron, mercury, lead, cadmium and nickel have been studied as a risk factor for hyperglycemia and diabetes. There is another group of metals that causes hypoglycemia such as vanadium, chromium, zinc and magnesium by different mechanisms. Zinc, magnesium and chromium deficiency is associated with increased risk of diabetes. This review summarizes some metals involved in glycemic control and pretends to alert health professionals about considering environmental metals as an important factor that could explain the poor glycemic control in patients. Further studies are needed to understand this poorly assessed problem.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2016.06.023