Older patients with low Charlson score and high-risk prostate cancer benefit from radical prostatectomy

Introduction The aim of the study was to identify the appropriate level of Charlson comorbidity index (CCI) in older patients (>70 years) with high-risk prostate cancer (PCa) to achieve survival benefit following radical prostatectomy (RP). Methods We retrospectively analyzed 1008 older patients...

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Bibliographic Details
Published in:World journal of urology 2016-10, Vol.34 (10), p.1367-1372
Main Authors: Sivaraman, A., Ordaz Jurado, G., Cathelineau, X., Barret, Eric, Dell’Oglio, P., Joniau, S., Bianchi, M., Briganti, A., Spahn, M., Bastian, P., Chun, J., Chlosta, P., Gontero, P., Graefen, M., Jeffrey Karnes, R., Marchioro, G., Tombal, B., Tosco, L., van der Poel, H. Henk, Sanchez-Salas, R.
Format: Article
Language:English
Subjects:
Aged
Biopsy
Follow-Up Studies
France - epidemiology
Humans
Male
Medicine
Medicine & Public Health
Neoplasm Grading - methods
Nephrology
Oncology
Original Article
Prostate - pathology
Prostate - surgery
Prostatectomy - methods
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - mortality
Prostatic Neoplasms - surgery
Retrospective Studies
Risk Assessment
Risk Factors
Survival Rate - trends
Time Factors
Urology
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Summary:Introduction The aim of the study was to identify the appropriate level of Charlson comorbidity index (CCI) in older patients (>70 years) with high-risk prostate cancer (PCa) to achieve survival benefit following radical prostatectomy (RP). Methods We retrospectively analyzed 1008 older patients (>70 years) who underwent RP with pelvic lymph node dissection for high-risk prostate cancer (preoperative prostate-specific antigen >20 ng/mL or clinical stage ≥T2c or Gleason ≥8) from 14 tertiary institutions between 1988 and 2014. The study population was further grouped into CCI 
ISSN:0724-4983
1433-8726
DOI:10.1007/s00345-016-1784-8