Measurement of transepidermal water loss (TEWL) in cats with experimental skin barrier dysfunction using a closed chamber system

Background A closed chamber evaporimeter is suitable for measuring transepidermal water loss (TEWL) in cats because of the compact device size, tolerance to sudden movement and short measuring time. TEWL is a representative parameter for skin barrier dysfunction, which is one of the clinical signs o...

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Bibliographic Details
Published in:Veterinary dermatology 2016-10, Vol.27 (5), p.428-e110
Main Authors: Momota, Yutaka, Shimada, Kenichiro, Gin, Azusa, Matsubara, Takako, Azakami, Daigo, Ishioka, Katsumi, Nakamura, Yuka, Sako, Toshinori
Format: Article
Language:English
Subjects:
Animals
Atopic dermatitis
Cats
Cats - physiology
Cosmetics industry
Coxa
Dermatitis
Disruption
Female
Male
Skin diseases
Skin Physiological Phenomena
Stratum corneum
Variation
Water loss
Water Loss, Insensible - physiology
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Summary:Background A closed chamber evaporimeter is suitable for measuring transepidermal water loss (TEWL) in cats because of the compact device size, tolerance to sudden movement and short measuring time. TEWL is a representative parameter for skin barrier dysfunction, which is one of the clinical signs of atopic dermatitis in humans and dogs. Measurement of feline TEWL has been reported, but applicability of this parameter has not been validated. Hypothesis/Objectives The aims of this study were to determine if tape stripping is a valid experimental model in cats for studying TEWL and to determine if a closed chambered system is a suitable measurement tool for cats. Animals Ten clinically normal cats. Methods In order to evaluate variation of the measured values, TEWL was measured at the right and left side of the three clipped regions (axillae, lateral thigh and groin). Subsequently, TEWL was measured using sequential tape stripping of the stratum corneum as a model of acute barrier disruption. Results The variations between both sides of the three regions showed no significant difference. Sequential tape stripping was associated with increasing values for TEWL. Conclusions and clinical importance Feline TEWL was shown to reflect changes in the skin barrier in an experimental model using a closed chamber system and has the potential for evaluating skin barrier function in cats with skin diseases. Résumé Contexte Un évaporomètre à chambre fermée est adapté pour la mesure de la TEWL (transepidermal water loss) chez le chat grâce à la taille compacte de l'appareil, à la tolérance aux mouvements brusques et au courts temps de mesure. La TEWL est un paramètre représentatif pour les anomalies de barrière cutanée qui est un des signes cliniques de la dermatite atopique de l'homme et du chien. La mesure de la TEWL féline a été rapportée mais l'applicabilité de ce paramètre n'a pas été validée. Hypothèses/Objectifs Les buts de cette étude étaient de déterminer si le «tape stripping» était un modèle expérimental valable chez le chat pour l’étude de la TEWL et de déterminer si un système en chambre fermée est un outil de mesure adapté au chat. Sujets Dix chats cliniquement sains. Méthodes Afin d’évaluer la variation des valeurs mesurées, la TEWL a été mesurée sur les régions droites et gauches de trois zones tondues (plis axillaires, cuisse latérale et pli inguinal). Ainsi la TEWL a été mesurée après tape stripping répété du stratum corneum comme modèle de rupture de bar
ISSN:0959-4493
1365-3164
DOI:10.1111/vde.12361