Molecular bases of aberrant miR-182 expression in ovarian cancer

The molecular bases of miR‐182 deregulation in epithelial ovarian cancers (EOCs) remain unknown and its diagnostic or prognostic role in EOCs is still unclear. We performed miR‐182 expression analysis using a microarray approach and real‐time PCR (qPCR). We also used array comparative genomic hybrid...

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Published in:Genes chromosomes & cancer 2016-11, Vol.55 (11), p.877-889
Main Authors: Marzec-Kotarska, Barbara, Cybulski, Marek, Kotarski, Józef Czesław, Ronowicz, Anna, Tarkowski, Rafał, Polak, Grzegorz, Antosz, Halina, Piotrowski, Arkadiusz, Kotarski, Jan
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - biosynthesis
Biomarkers, Tumor - genetics
Cell Proliferation - genetics
Comparative Genomic Hybridization
Disease-Free Survival
DNA Methylation - genetics
DNA-Binding Proteins - genetics
Female
Gene Expression Regulation, Neoplastic - genetics
Humans
MicroRNAs - biosynthesis
MicroRNAs - genetics
Middle Aged
Ovarian cancer
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Prognosis
Promoter Regions, Genetic
Transcription Factors - genetics
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Summary:The molecular bases of miR‐182 deregulation in epithelial ovarian cancers (EOCs) remain unknown and its diagnostic or prognostic role in EOCs is still unclear. We performed miR‐182 expression analysis using a microarray approach and real‐time PCR (qPCR). We also used array comparative genomic hybridization and methylated DNA immunoprecipitation to study copy number changes and methylation aberrations within coding locus/promoter sequences of miR‐182 in EOC tissues, respectively. We have found that miR‐182 expression is significantly increased in EOC (P 
ISSN:1045-2257
1098-2264
DOI:10.1002/gcc.22387