Heterogeneous copper concentrations in cancerous human prostate tissues

Background Therapeutics that target copper for the treatment of prostate cancer are being evaluated in human clinical trials. Elevated intracellular copper is considered to sensitize prostate cancer cells to certain copper‐coordination compounds, especially those with ionophoric properties. While th...

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Bibliographic Details
Published in:The Prostate 2015-10, Vol.75 (14), p.1510-1517
Main Authors: Denoyer, Delphine, Clatworthy, Sharnel A.S., Masaldan, Shashank, Meggyesy, Peter M., Cater, Michael A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
benign prostatic hyperplasia
Biomarkers, Tumor - blood
Biomarkers, Tumor - metabolism
copper
Copper - blood
Copper - metabolism
Humans
ionophore
Male
Middle Aged
prostate cancer
Prostatectomy
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - metabolism
treatment
Victoria - epidemiology
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Summary:Background Therapeutics that target copper for the treatment of prostate cancer are being evaluated in human clinical trials. Elevated intracellular copper is considered to sensitize prostate cancer cells to certain copper‐coordination compounds, especially those with ionophoric properties. While there is compelling in vitro evidence that prostate cancer cells accumulate intracellular copper, a corresponding status for copper in patient tissues has not been corroborated. We therefore established whether copper concentrations increase in cancerous prostate tissues, and in sera, in patients throughout disease progression. Methods Human prostate tissue samples were obtained from patient prostatectomies (n = 28), and together with patient‐matched sera, were analyzed for copper content by inductively coupled plasma mass spectrometry. Results When grouped together, cancerous prostate tissues exhibiting moderate disease severity (Gleason Score 7) (n = 10) had 1.6‐fold more copper than age‐matched normal tissues (n = 10) (P 
ISSN:0270-4137
1097-0045
DOI:10.1002/pros.23022