The association of DENND1A gene polymorphisms and polycystic ovary syndrome risk: a systematic review and meta-analysis

Purpose Polycystic ovary syndrome is heterogeneity disease, and the association with DEEND1A gene has been discussed incompatibly for a long time. We conducted a meta-analysis to evaluate the rs10818854, rs2479106, and rs10986105 polymorphism in DENND1A gene with PCOS susceptibility. Methods Meta-an...

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Published in:Archives of gynecology and obstetrics 2016-11, Vol.294 (5), p.1073-1080
Main Authors: Gao, Jing, Xue, Jing-Dong, Li, Zhi-Chao, Zhou, Li, Chen, Chen
Format: Article
Language:English
Subjects:
Death Domain Receptor Signaling Adaptor Proteins - genetics
Endocrinology
Female
Genetic Predisposition to Disease - genetics
Guanine Nucleotide Exchange Factors - genetics
Gynecologic Endocrinology and Reproductive Medicine
Gynecology
Human Genetics
Humans
Medicine
Medicine & Public Health
Meta-analysis
Obstetrics/Perinatology/Midwifery
Polycystic ovary syndrome
Polycystic Ovary Syndrome - genetics
Polymorphism
Polymorphism, Genetic
Risk Factors
Systematic review
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Summary:Purpose Polycystic ovary syndrome is heterogeneity disease, and the association with DEEND1A gene has been discussed incompatibly for a long time. We conducted a meta-analysis to evaluate the rs10818854, rs2479106, and rs10986105 polymorphism in DENND1A gene with PCOS susceptibility. Methods Meta-analysis was performed for common allele versus rare allele using random effect model on published papers from January 1, 1980 to October 1, 2015. Subgroup analysis, sensitivity analysis and publication bias were also carried out ultimately. The combined odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated to estimate the strength of the association. Results The results showed that rs10818854 (OR = 1.36, 95 % CI 1.12–1.61) and rs10986105 (OR = 1.39, 95 % CI 1.20–1.58) polymorphism increased the risk of PCOS probably. A significant association was also found between rs2479106 mutation and Asian PCOS patients but not Europeans (OR = 1.32, 95 % CI 1.25–1.39; OR = 1.01, 95 % CI 0.97–1.05, respectively). Conclusions In conclusion, the DENND1A gene variant is likely to have influence on PCOS risk. Further studies are warranted to assess these associations in greater detail, especially in different populations and different subtype of PCOS patients.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-016-4159-x