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German registry of paediatric deep brain stimulation in patients with childhood-onset dystonia (GEPESTIM)
Abstract Background Data on paediatric DBS is limited, especially for long-term outcomes, because of small numbers in single center series and lack of systematic multi-center trials. Objectives We seek to systematically evaluate the clinical outcome of paediatric patients undergoing DBS. Methods A G...
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Published in: | European journal of paediatric neurology 2017-01, Vol.21 (1), p.136-146 |
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Main Authors: | , , , , , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
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Online Access: | Get full text |
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Summary: | Abstract Background Data on paediatric DBS is limited, especially for long-term outcomes, because of small numbers in single center series and lack of systematic multi-center trials. Objectives We seek to systematically evaluate the clinical outcome of paediatric patients undergoing DBS. Methods A German registry on paediatric DBS (GEPESTIM) was created to collect data of patients with dystonia and DBS up to the age of 18 years. Patients were divided into three groups according to etiology (group 1 inherited, group 2 acquired, and group 3 idiopathic dystonia). Results Data of 44 patients with a mean age of 12.8 years at time of operation provided by 6 German centers could be documented in the registry so far (group 1 n=23, group 2 n=16, group 3 n=5). Average absolute improvement after implantation was 15.5±18.0 for 27 patients with pre- and postoperative Burke-Fahn-Marsden Dystonia Rating scale movement scores available (p |
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ISSN: | 1090-3798 1532-2130 |
DOI: | 10.1016/j.ejpn.2016.05.023 |