Maternal monocytes in pregnancy and preeclampsia in humans and in rats

Highlights • Monocyte activation and maturation was observed in pregnancy. • Further monocyte activation and maturation was observed in preeclampsia. • During rat pregnancy, similar changes occur in monocytes as during human pregnancy. • In rat models for preeclampsia, similar changes in monocytes o...

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Bibliographic Details
Published in:Journal of reproductive immunology 2017-02, Vol.119, p.91-97
Main Authors: Faas, M.M, de Vos, P
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Disease Models, Animal
Female
Humans
Inflammation - immunology
Monocyte subsets
Monocytes
Monocytes - immunology
Obstetrics and Gynecology
Pre-Eclampsia - immunology
Preeclampsia
Pregnancy
Pregnancy - immunology
Rat
Rats
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Summary:Highlights • Monocyte activation and maturation was observed in pregnancy. • Further monocyte activation and maturation was observed in preeclampsia. • During rat pregnancy, similar changes occur in monocytes as during human pregnancy. • In rat models for preeclampsia, similar changes in monocytes occur as during human preeclampsia. • The rat is a useful model to study monocyte changes in pregnancy and experimental preeclampsia.
ISSN:0165-0378
1872-7603
DOI:10.1016/j.jri.2016.06.009