Current and emerging treatment options for spinal cord ischemia

•Spinal cord ischemia is a rare but disabling disorder.•We summarize current and emerging treatment concepts.•There is a lack of randomized controlled trials.•Several neuroprotective treatment options await translational adoption. Spinal cord infarction (SCI) is a rare but disabling disorder caused...

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Bibliographic Details
Published in:Drug discovery today 2016-10, Vol.21 (10), p.1632-1641
Main Authors: Nardone, Raffaele, Pikija, Slaven, Mutzenbach, J. Sebastian, Seidl, Martin, Leis, Stefan, Trinka, Eugen, Sellner, Johann
Format: Article
Language:English
Subjects:
Animals
Humans
Neuroprotective Agents - therapeutic use
Prognosis
Spinal Cord Ischemia - drug therapy
Spinal Cord Ischemia - etiology
Spinal Cord Ischemia - prevention & control
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Summary:•Spinal cord ischemia is a rare but disabling disorder.•We summarize current and emerging treatment concepts.•There is a lack of randomized controlled trials.•Several neuroprotective treatment options await translational adoption. Spinal cord infarction (SCI) is a rare but disabling disorder caused by a wide spectrum of conditions. Given the lack of randomized-controlled trials, contemporary treatment concepts are adapted from guidelines for cerebral ischemia, atherosclerotic vascular disease, and acute traumatic spinal cord injury. In addition, patients with SCI are at risk for several potentially life-threatening but preventable systemic and neurologic complications. Notably, there is emerging evidence from preclinical studies for the use of neuroprotection in acute ischemic injury of the spinal cord. In this review, we discuss the current state of the art for the therapy and prevention of SCI and highlight potential emerging treatment concepts awaiting translational adoption. Spinal cord infarction is a rare but often devastating condition. Here, we discuss emerging treatment concepts awaiting translational adoption.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2016.06.015