Concentrations of prealbumin and some appetite-controlling hormones in pregnancies associated with hyperemesis gravidarium

Background Hyperemesis gravidarum, which affects 0.3–2.3% of pregnancies, is defined as excessive vomiting during pregnancy and usually starts in week 4 or 5 of gestation. Symptoms include weight loss, dehydration, ketonaemia, ketonuria, fasting acidosis, alkalosis due to hydrochloric acid loss and...

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Bibliographic Details
Published in:Annals of clinical biochemistry 2017-03, Vol.54 (2), p.258-263
Main Authors: Ozturk, Gulfer, Ozgu-Erdinc, A Seval, Ucar, Fatma, Ginis, Zeynep, Erden, Gonul, Danisman, Nuri
Format: Article
Language:English
Subjects:
Adult
Appetite - physiology
Body Mass Index
Calcium-Binding Proteins - blood
Calcium-Binding Proteins - genetics
Case-Control Studies
DNA-Binding Proteins - blood
DNA-Binding Proteins - genetics
Fasting - psychology
Female
Gene Expression Regulation
Gestational Age
Ghrelin - blood
Ghrelin - genetics
Humans
Hyperemesis Gravidarum - blood
Hyperemesis Gravidarum - diagnosis
Hyperemesis Gravidarum - genetics
Hyperemesis Gravidarum - physiopathology
Nerve Tissue Proteins - blood
Nerve Tissue Proteins - genetics
Prealbumin - genetics
Prealbumin - metabolism
Pregnancy
Signal Transduction
Weight Loss
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Summary:Background Hyperemesis gravidarum, which affects 0.3–2.3% of pregnancies, is defined as excessive vomiting during pregnancy and usually starts in week 4 or 5 of gestation. Symptoms include weight loss, dehydration, ketonaemia, ketonuria, fasting acidosis, alkalosis due to hydrochloric acid loss and hypokalaemia and its exact cause is unknown. The present study was undertaken to investigate the relationship between prealbumin, ghrelin, nesfatin-1 and obestatin concentrations in pregnancies associated with hyperemesis gravidarum. Methods A total of 40 pregnant females with hyperemesis gravidarum and 38 pregnant females without hyperemesis gravidarum as controls were included in this study. Serum concentrations of prealbumin, ghrelin, obestatin and nesfatin-1 were measured. Results There were no significant differences in age, gestational week, gravidity and parity between the two groups. Body mass index was significantly lower in cases than in controls. Serum ghrelin and prealbumin concentrations were significantly lower in cases than in controls (P  
ISSN:0004-5632
1758-1001
DOI:10.1177/0004563216654724