Respiratory supercomplexes and the functional segmentation of the CoQ pool

The evidence accumulated during the last fifteen years on the existence of respiratory supercomplexes and their proposed functional implications has changed our understanding of the OXPHOS system complexity and regulation. The plasticity model is a point of encounter accounting for the apparently co...

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Bibliographic Details
Published in:Free radical biology & medicine 2016-11, Vol.100, p.5-13
Main Authors: Moreno-Loshuertos, Raquel, Enríquez, José Antonio
Format: Article
Language:English
Subjects:
Animals
Cell Respiration
CoQ pool
Humans
mETC assembly
Models, Biological
Oxidative Phosphorylation
OXPHOS system
Plasticity model
Respiratory supercomplex
ROS
Ubiquinone - metabolism
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Summary:The evidence accumulated during the last fifteen years on the existence of respiratory supercomplexes and their proposed functional implications has changed our understanding of the OXPHOS system complexity and regulation. The plasticity model is a point of encounter accounting for the apparently contradictory experimental observations claimed to support either the solid or the fluid models. It allows the explanation of previous observations such as the dependence between respiratory complexes, supercomplex assembly dynamics or the existence of different functional ubiquinone pools. With the general acceptation of respiratory supercomplexes as true entities, this review evaluates the supporting evidences in favor or against the existence of different ubiquinone pools and the relationship between supercomplexes, ROS production and pathology. •The plasticity model explains OXPHOS system organization and predicts SCs dynamics.•CoQ segmentation contradictory views can be reconciled by the plasticity model.•SCs organization is involved in ROS prevention.•SCs alterations are linked to ROS-related pathological and physiological processes.
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2016.04.018