Eradication failure of newly acquired Pseudomonas aeruginosa isolates in cystic fibrosis

Abstract Eradication of Pseudomonas aeruginosa (PA) is critical in cystic fibrosis (CF) patients. Objectives To determine eradication success rate of newly acquired PA and to identify characteristics associated with eradication failure. Methods In an observational study, data from patients with newl...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cystic fibrosis 2016-11, Vol.15 (6), p.776-782
Main Authors: Cohen-Cymberknoh, Malena, Gilead, Noa, Gartner, Silvia, Rovira, Sandra, Blau, Hannah, Mussaffi, Huda, Rivlin, Joseph, Gur, Michal, Shteinberg, Michal, Bentur, Lea, Livnat, Galit, Aviram, Micha, Picard, Elie, Tenenbaum, Ariel, Armoni, Shoshana, Breuer, Oded, Shoseyov, David, Kerem, Eitan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - therapeutic use
Child
Cystic fibrosis
Cystic Fibrosis - complications
Cystic Fibrosis - epidemiology
Cystic Fibrosis - microbiology
Cystic Fibrosis - therapy
Drug Resistance, Multiple, Bacterial
Eradication failure
Female
Humans
Infant
Infection Control - methods
Infection Control - statistics & numerical data
Israel - epidemiology
Male
Medication Therapy Management
Middle Aged
Outcome and Process Assessment (Health Care)
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - isolation & purification
Pseudomonas aeruginosa - pathogenicity
Pseudomonas infection
Pseudomonas Infections - diagnosis
Pseudomonas Infections - drug therapy
Pseudomonas Infections - epidemiology
Pseudomonas Infections - etiology
Pulmonary/Respiratory
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Eradication of Pseudomonas aeruginosa (PA) is critical in cystic fibrosis (CF) patients. Objectives To determine eradication success rate of newly acquired PA and to identify characteristics associated with eradication failure. Methods In an observational study, data from patients with newly acquired PA infection from 2007 to 2013 were collected. Clinical variables were compared in patients with and without successful eradication for ≥ 1 year. Results Of 183 patients out of 740 (25%) from 7 CF Centers that had newly acquired PA, eradication succeeded in 72%. Patients with the highest risk of failure had multi-resistant PA, fewer sputum cultures taken, were older, and were diagnosed at a later age. The risk of eradication failure increased by 1.3% with each year of delayed CF diagnosis; successful eradication increased by 17% with each additional sputum culture taken. Conclusions Delayed detection of PA infection leading to delayed treatment and growth of multi-resistant organisms is associated with eradication failure.
ISSN:1569-1993
1873-5010
DOI:10.1016/j.jcf.2016.04.006