Epidemiological characteristics of a Spanish cohort of patients diagnosed with squamous cell carcinoma of head and neck: distribution of risk factors by tumor location

Purpose Head and neck cancer is a highly heterogeneous disease comprising a large number of tumors located in the cervicofacial area. This study aimed to determine the epidemiological characteristics of squamous-cell carcinomas of the head and neck in the Spanish population, and the distribution of...

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Published in:Clinical & translational oncology 2016-11, Vol.18 (11), p.1114-1122
Main Authors: Seijas-Tamayo, R., Fernández-Mateos, J., Adansa Klain, J. C., Mesía, R., Pastor Borgoñón, M., Pérez-Ruiz, E., Vázquez Fernández, S., Salvador Coloma, C., Rueda Domínguez, A., Taberna, M., Martínez-Trufero, J., Bonfill Abella, T., Vázquez Estévez, S., Pollán, M., del Barco Morillo, E., Cruz-Hernández, J. J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alcohol Drinking - adverse effects
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - pathology
Female
Head and Neck Neoplasms - epidemiology
Head and Neck Neoplasms - etiology
Head and Neck Neoplasms - pathology
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Research Article
Risk Factors
Smoking - adverse effects
Spain - epidemiology
Squamous Cell Carcinoma of Head and Neck
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Summary:Purpose Head and neck cancer is a highly heterogeneous disease comprising a large number of tumors located in the cervicofacial area. This study aimed to determine the epidemiological characteristics of squamous-cell carcinomas of the head and neck in the Spanish population, and the distribution of risk factors based on tumor locations. Methods/patients A cohort of 459 patients (75 oral cavity, 167 oro-/hypopharyngeal and 217 laryngeal cancers) recruited in 19 hospitals participating in the Spanish head and neck cancer cooperative group were included over 3 years (2012–2014). Epidemiological parameters and risk factors were obtained from a self-administered questionnaire, and tumor characteristics were obtained from clinical records. Multivariate multinomial logistic regression was used to assess factors associated with tumor location. Results Most patients were males (88.4 %), smokers (95 %) and drinkers (76.5 %). Relative to laryngeal cancer, pharyngeal cancer and oral cancer were more common in women than men (OR 3.58, p  = 0.003 and 4.33, p  = 0.001, respectively); pharyngeal cancer was more associated with rural environment (OR 1.81, p  = 0.007) and weekly alcohol intake (10–140 g: OR 2.53, p  = 0.012; 141–280 g: OR 2.47, p  = 0.023; >280 g: OR 3.20, p  = 0.001) and less associated with pack-years of smoking (21–40 packs: OR 0.46, p  = 0.045; 41–70 packs: OR 0.43, p  = 0.023; ≥71 packs: OR 3.20, p  = 0.015). Conclusions The distribution of these tumors differs between the sexes, with a higher proportion of oral cavity and pharyngeal tumors in women than in men. Oro-/hypopharyngeal cancers were more strongly associated with rural areas and with alcohol consumption, although less strongly associated with smoking than laryngeal tumors.
ISSN:1699-048X
1699-3055
DOI:10.1007/s12094-016-1493-1