High frequency of CYP2D6 ultrarapid metabolizer genotypes in an Ashkenazi Jewish population from Argentina

A twofold higher frequency of CYP2D6 ultrarapid metabolizers (estimated from genotype: gUMs) was reported among Ashkenazi Jews (AJ) living in New York (USA) than in other North American Caucasians, which might be important to guide the prescription for CYP2D6 substrates in AJ communities around the...

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Bibliographic Details
Published in:The pharmacogenomics journal 2017-07, Vol.17 (4), p.378-381
Main Authors: Moya, G, Dorado, P, Ferreiro, V, Naranjo, M E G, Peñas-Lledó, E M, LLerena, A
Format: Article
Language:English
Subjects:
19th century
20th century
Alleles
Argentina
Ashkenazim
Continental Population Groups - genetics
CYP2D6 protein
Cytochrome P-450 CYP2D6 - genetics
Cytochrome P450
Deoxyribonucleic acid
DNA
Enzymes
Gene Frequency - genetics
Gene polymorphism
Genes
Genetic aspects
Genotype
Genotype & phenotype
Genotypes
Genotyping
Gums
Humans
Immigration
Isoenzymes
Jewish people
Laboratories
Phenotype
Phenotypes
Polymorphism
Population
Population studies
Substrates
White people
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Summary:A twofold higher frequency of CYP2D6 ultrarapid metabolizers (estimated from genotype: gUMs) was reported among Ashkenazi Jews (AJ) living in New York (USA) than in other North American Caucasians, which might be important to guide the prescription for CYP2D6 substrates in AJ communities around the world. This study was aimed to determine whether the high frequency of CYP2D6 gUMs described in AJ from USA was replicated in AJ from Argentina when compared with other multiethnic admixture Argentines (GA). The frequency of the most common allelic variants and of CYP2D6 gUMs (>2 active genes) and poor metabolizers (0 active genes, gPMs) was also compared among the studied Argentine populations. CYP2D6 genotyping was performed in 173 AJ and 246 GA DNA samples of unrelated donors from the metropolitan area of Buenos Aires. CYP2D6 alleles (*2, *3, *4, *5, *6, *10, *17, *35, *41 and multiple copies), genotypes and functional phenotype frequencies were determined. The frequencies of gUMs and gPMs in AJ from Argentina were 11.5% and 5.2%, respectively, whereas in GA, the frequencies of gUM and gPMs were 6.5% and 4.9%, respectively. Comparisons between AJ and GA showed that gUMs frequencies were twofold higher (P
ISSN:1470-269X
1473-1150
DOI:10.1038/tpj.2016.27